TY - JOUR AU - Boonmasawai, Sookruetai AU - Sariya, Ladawan AU - Leesombun, Arpron AU - Chaichoun, Kridsada AU - Taowan, Jarupha AU - Thongjuy, Orathai PY - 2019/03/11 Y2 - 2024/03/28 TI - Anti-proliferative and total ERK1/2 inhibitory effects of plant flavonols on Human cervical cancer (HeLa) cells JF - The Thai Journal of Veterinary Medicine JA - TJVM VL - 48 IS - 4 SE - Original Articles DO - UR - https://he01.tci-thaijo.org/index.php/tjvm/article/view/176929 SP - 541-549 AB - <p><span class="fontstyle0">Kaempferol, myricetin and quercetin are abundant flavonols in edible fruit and vegetables</span><span class="fontstyle2">. </span><span class="fontstyle0">Much previous<br>data has shown the beneficial effects of these flavonols in cancer treatments</span><span class="fontstyle2">. </span><span class="fontstyle0">Thus, the cytotoxic effects on rhesus<br>monkey kidney epithelial cells </span><span class="fontstyle2">(</span><span class="fontstyle0">LLC</span><span class="fontstyle2">-</span><span class="fontstyle0">MK2</span><span class="fontstyle2">) </span><span class="fontstyle0">and the anti</span><span class="fontstyle2">-</span><span class="fontstyle0">proliferative effects on human cervical cancer </span><span class="fontstyle2">(</span><span class="fontstyle0">HeLa</span><span class="fontstyle2">) </span><span class="fontstyle0">cells<br>through total ERK protein expression of kaempferol, myricetin and quercetin have been investigated</span><span class="fontstyle2">. </span><span class="fontstyle0">The cytotoxic<br>assay at 24h revealed the high safety of three flavonols on LLC</span><span class="fontstyle2">-</span><span class="fontstyle0">MK2 cells</span><span class="fontstyle2">. </span><span class="fontstyle0">Kaempferol </span><span class="fontstyle2">(</span><span class="fontstyle0">1</span><span class="fontstyle2">-</span><span class="fontstyle0">1000 µM</span><span class="fontstyle2">) </span><span class="fontstyle0">did not have any<br>significant effect on the viability of these normal epithelial cells</span><span class="fontstyle2">. </span><span class="fontstyle0">The cytotoxicity of myricetin and quercetin was 5 µM<br>and 50 µM, respectively</span><span class="fontstyle2">. </span><span class="fontstyle0">No flavonols could suppress total ERK</span><span class="fontstyle2">1/2 </span><span class="fontstyle0">protein expression in LLC</span><span class="fontstyle2">-</span><span class="fontstyle0">MK2 cells</span><span class="fontstyle2">. </span><span class="fontstyle0">In HeLa cells,<br>kaempferol </span><span class="fontstyle2">(</span><span class="fontstyle0">5 µM</span><span class="fontstyle2">) </span><span class="fontstyle0">and quercetin </span><span class="fontstyle2">(</span><span class="fontstyle0">1 µM</span><span class="fontstyle2">) </span><span class="fontstyle0">significantly inhibited cell proliferations and total ERK1</span><span class="fontstyle2">/</span><span class="fontstyle0">2 protein expression</span><span class="fontstyle2">.<br></span><span class="fontstyle0">Myricetin significantly reduced cancer cell proliferations at 1 µM without any effect on total ERK1</span><span class="fontstyle2">/</span><span class="fontstyle0">2 protein expression</span><span class="fontstyle2">.<br></span><span class="fontstyle0">In conclusion, kaempferol and quercetin had an inhibitory effect on HeLa cells via reduction of total ERK1</span><span class="fontstyle2">/</span><span class="fontstyle0">2 protein at<br>24h</span><span class="fontstyle2">. </span><span class="fontstyle0">But the anti</span><span class="fontstyle2">-</span><span class="fontstyle0">proliferative effects of myricetin did not exert via total ERK1</span><span class="fontstyle2">/</span><span class="fontstyle0">2 protein expression</span><span class="fontstyle2">. </span><span class="fontstyle0">This study affirms<br>the potency of three flavonols as future chemotherapeutic agents and herbal supplements</span><span class="fontstyle2">.</span> </p> ER -