TY - JOUR AU - Tachampa, Kittipong AU - Lertwanakarn, Tuchakorn AU - Atchariyasakchai, Panupong AU - Pumpitakkul, Vichayanee AU - Kireewan, Supapatt AU - Buranakarl, Chollada PY - 2018/09/20 Y2 - 2024/03/28 TI - Effects of coenzyme Q10 supplementation on cardiac troponin I level, heart rate variability, and echocardiographic profiles in canine with myxomatous degenerative mitral valve disease: a pilot study JF - The Thai Journal of Veterinary Medicine JA - TJVM VL - 48 IS - 3 SE - Original Articles DO - UR - https://he01.tci-thaijo.org/index.php/tjvm/article/view/146580 SP - 443-452 AB - <p><span class="fontstyle0">The clinical benefits of Coenzyme Q10 (CoQ10) have been well documented in heart failure patients. In<br>veterinary medicine, however, the clinical benefits of CoQ10 have not been well established in dogs with heart diseases.<br>This study aimed to determine the effects of CoQ10 supplementation on 1) preventing myocardial injury 2) cardiac<br>function 3) autonomic balance in dogs with myxomatous degenerative mitral valve disease (MMVD). Thirteen dogs<br>with MMVD at ACVIM stage C were recruited in this study. Dogs were further divided into group I (Body weight<br>[BW] &lt; 6 kg.; n = 7) and group II (BW ≥ 6 kg.; n = 6). Cardiac troponin I (cTnI), echocardiographic examination, and 2<br>hours of Holter recording were performed on Day 0 and after receiving CoQ10 at 100 mg/dog twice daily for 28 days.<br>CoQ10 caused a reduction of cTnI level in 71% of the dogs. Median cTnI tended to cause tended to decline but not<br>significantly. Systolic function [i.e. fractional shortening (FS) and ejection fraction (EF)] increased significantly by 8 %<br>and 9% (P &lt; 0.05), respectively in group I after CoQ10 supplementation. Other echocardiographic parameters were not<br>altered in either group. HRV analysis revealed no change in autonomic function and balance. cTnI negatively correlated<br>with FS (P &lt; 0.01) and positively correlated with LF/HF ratio (P &lt; 0.05). In conclusion, this study demonstrated the<br>clinical benefits of CoQ10 supplementation in dogs with MMVD. CoQ10 improves cardiac function in small dogs with<br>MMVD. Finally, supplementation of CoQ10 in dogs should be based on body weight.</span> </p> ER -