@article{ATASEVER_YAMAN GRAM_EKEBAS_ERTAS ONMAZ_SENTURK_EREN_EKICI_2020, title={Effect of fermented red radish (Raphanus sativus L) in carbon tetrachloride-induced liver injury in rats}, volume={50}, url={https://he01.tci-thaijo.org/index.php/tjvm/article/view/245851}, abstractNote={<p><span class="fontstyle0">In this study, the possible protective effect of red radish containing total phenolic content and antioxidant<br>components on histopathological and immuno histochemical active caspase-3, TNF-α and Iba-1, serum ALT activity,<br>triglyceride, total cholesterol, LDL-cholesterol, liver malondialdehyde (MDA) and nitric oxide (NO) levels were<br>evaluated in CCl</span><span class="fontstyle0">4 </span><span class="fontstyle0">induced liver injury in Wistar rats. The rats were randomly divided into six groups (n= 12 to each<br>group). The first group was used as a control which was given only intraperitoneal 0.9% NaCl (0.2 mL / kg / bw);<br>while fermented red radish (FRR) at a dose of 250 mg/kg or 500 mg/kg was given daily by intragastric administration<br>to group II and group III, respectively for seven consecutive days. Carbon tetrachloride (CCl</span><span class="fontstyle0">4</span><span class="fontstyle0">) diluted 1:1 ratio in corn<br>oil and was given (1.5 mL/kg) to the rats in group IV by intraperitoneal injection. Group V and VI received FRR at a<br>dose of 250 mg/kg or 500 mg/kg, respectively for seven consecutive days prior to CCl</span><span class="fontstyle0">4 </span><span class="fontstyle0">injection. Pretreatment with<br>FRR at 250 mg/kg and 500 mg/kg followed by CCl</span><span class="fontstyle0">4 </span><span class="fontstyle0">exposure had no ameliorative effect on the histopathological<br>changes in the liver. It is thought that FRR application has a partial antioxidative effect by decreasing the biochemical<br>and lipid peroxidation levels in the control group but this is not effective in the treatment of damage to liver tissue. In<br>conclusion, it has been concluded that new investigations should be done to determine the healing effects of red radish<br>on fermented tissues using different doses to give the best results without any side effects.</span> </p>}, number={3}, journal={The Thai Journal of Veterinary Medicine}, author={ATASEVER, Ayhan and YAMAN GRAM, Duygu and EKEBAS, Gorkem and ERTAS ONMAZ, Nurhan and SENTURK, Meryem and EREN, Meryem and EKICI, Lutfiye}, year={2020}, month={Sep.}, pages={405–416} }