@article{Songsri_Ketthaisong_Boonmars_Boueroy_Laummaunwai_Vaeteewoottacharn_Rattanasuwan_Boonyarat_Lomthaisong_Tangwongchai_Borlace_2020, title={In Vitro and In Vivo effect of Chia oil (Salvia hispanica L.) on Haplorchis taichui}, volume={49}, url={https://he01.tci-thaijo.org/index.php/tjvm/article/view/240499}, abstractNote={<p><span class="fontstyle0">Haplorchis taichui </span><span class="fontstyle2">is an intestinal heterophyid fluke that is pathogenic to humans. This parasite can mature in the<br>small intestine of birds and mammals. The purpose of this study was to investigate the effect of chia seed oil (</span><span class="fontstyle0">Salvia<br>hispanica </span><span class="fontstyle2">L.) on </span><span class="fontstyle0">H. taichui in vitro </span><span class="fontstyle2">and </span><span class="fontstyle0">in vivo</span><span class="fontstyle2">. The activity of adult </span><span class="fontstyle0">H. taichui </span><span class="fontstyle2">worms incubated in Tyrode’s solution<br>containing praziquantel (10µg/ml) or chia oil (1 or 10 mg/ml) for 1, 6, 12 and 24 hours was assessed by observation<br>under a stereo-microscope. Syrian hamsters infected with 200 </span><span class="fontstyle0">H. taichui </span><span class="fontstyle2">metacercariae were treated with 25mg/kgBW<br>praziquantel in a single dose or 100mg/kgBW chia oil for 3 days. The number of worms recovered from the small<br>intestine was determined and morphology was examined by scanning electron microscopy (SEM). All the worms were<br>inactive and contracted after 1h exposure to 10 µg/ml praziquantel. Twenty percent of the worms were inactive after<br>exposure to 1 mg/ml of chia oil for 12 h and 100% of the worms were inactive after exposure to 10 mg/ml chia oil for<br>1 h. The average number of adult </span><span class="fontstyle0">H. taichui </span><span class="fontstyle2">worms recovered from the intestines of hamsters treated with chia oil was<br>60 ± 11.57 and SEM analysis showed time and concentration dependent blebbing, swelling and sloughing of the<br>tegument surface. There were no worms recovered from the hamsters treated with praziquantel. The blebbing and<br>sloughing results of chia oil on the </span><span class="fontstyle0">H. taichui </span><span class="fontstyle2">covering looked similar to those of praziquantel.</span> </p>}, number={4}, journal={The Thai Journal of Veterinary Medicine}, author={Songsri, Jiraporn and Ketthaisong, Danupol and Boonmars, Thidarut and Boueroy, Parichart and Laummaunwai, Porntip and Vaeteewoottacharn, Kulthida and Rattanasuwan, Panaratana and Boonyarat, Chantana and Lomthaisong, Khomsorn and Tangwongchai, Ratchada and Borlace, Glenn N}, year={2020}, month={Mar.}, pages={393–400} }