@article{Jiratitipat_Srikhong_Wanasawaeng_Chansiripornchai_2020, title={Efficacy of competitive exclusion to reduce Salmonella in broiler chickens}, volume={49}, url={https://he01.tci-thaijo.org/index.php/tjvm/article/view/240498}, abstractNote={<p><span class="fontstyle0">Competitive exclusion </span><span class="fontstyle2">(</span><span class="fontstyle0">CE</span><span class="fontstyle2">) </span><span class="fontstyle0">relies on the activity of normal flora to limit intestinal colonization by enteric pathogens</span><span class="fontstyle2">.<br></span><span class="fontstyle0">This study aims to investigate the effects of CE on </span><span class="fontstyle3">Salmonella </span><span class="fontstyle0">infection in broilers</span><span class="fontstyle2">. </span><span class="fontstyle0">The protective effect of CE on<br></span><span class="fontstyle3">Salmonella </span><span class="fontstyle0">cecal colonization was evaluated in 1 day</span><span class="fontstyle2">-</span><span class="fontstyle0">old chicks</span><span class="fontstyle2">. </span><span class="fontstyle0">In the laboratory trial, CE products were administered<br>by oral inoculation, drinking water and whole body spray</span><span class="fontstyle2">. </span><span class="fontstyle0">Three days after treatment, the chickens were challenged<br>with 10</span><span class="fontstyle0">7</span><span class="fontstyle0">cfu</span><span class="fontstyle2">/ </span><span class="fontstyle0">mL of </span><span class="fontstyle3">Salmonella </span><span class="fontstyle0">Enteritidis orally, and were evaluated for 10 days</span><span class="fontstyle2">. </span><span class="fontstyle0">The CE</span><span class="fontstyle2">- </span><span class="fontstyle0">treated chickens showed<br>comparable protection and the number of </span><span class="fontstyle3">Salmonella </span><span class="fontstyle0">in the cecal contents significantly decreased </span><span class="fontstyle2">(</span><span class="fontstyle3">P </span><span class="fontstyle0">< 0</span><span class="fontstyle2">.</span><span class="fontstyle0">05</span><span class="fontstyle2">) </span><span class="fontstyle0">compared<br>with those of the positive control</span><span class="fontstyle2">. </span><span class="fontstyle0">In the farm trial, CE was administered by whole body spray at the hatchery and the<br>second was administered by drinking water and evaluated at 32 and 42 days, respectively</span><span class="fontstyle2">.</span><span class="fontstyle0">The CE significantly reduced<br></span><span class="fontstyle3">Salmonella </span><span class="fontstyle0">contamination in the farm trial and no </span><span class="fontstyle3">Salmonella </span><span class="fontstyle0">was detected in the cecal contents compared with the<br>control group</span><span class="fontstyle2">.</span><span class="fontstyle0">Average body weight gains, feed conversion ratio and theperformance index of the chickens were greater<br>than the </span><span class="fontstyle3">control group</span><span class="fontstyle2">. </span><span class="fontstyle0">Thus, the use of CE had a positive effect on broiler performance</span><span class="fontstyle2">. </span><span class="fontstyle0">Furthermore, the CE</span><span class="fontstyle2">-</span><span class="fontstyle0">treated<br>chickens displayed greater intestinal histology including villous height, submuscular layer and cell mitosis</span><span class="fontstyle2">. </span><span class="fontstyle0">These<br>studies demonstrate that CE was able to protect chickens from </span><span class="fontstyle3">Salmonella </span><span class="fontstyle0">cecal colonization and it is apparent that new<br>methodologies associated with the development of a workable CE program are needed in the poultry industry</span><span class="fontstyle2">.</span> </p>}, number={4}, journal={The Thai Journal of Veterinary Medicine}, author={Jiratitipat, Nattaporn and Srikhong, Prapasri and Wanasawaeng, Wisanu and Chansiripornchai, Niwat}, year={2020}, month={Mar.}, pages={385–391} }