@article{Boonsoongnern_Jirawattanapong_Surachetpong_Boonsoongnern_Poolperm_2019, title={Effect of oxidized soybean oil on the immune response to porcine reproductive and respiratory syndrome modified live virus vaccine in nursery pigs}, volume={49}, url={https://he01.tci-thaijo.org/index.php/tjvm/article/view/231580}, abstractNote={<p><span class="fontstyle0">This study evaluated the effect of oxidized soybean oil on the immune response to porcine reproductive and<br>respiratory syndrome modified live vaccine (PRRS-MLV), and the oxidative stress status in nursery pigs. Seventy<br>castrated weaned pigs, from a free PRRS virus infected herd, were divided into two groups: treatment group (n=63)<br>and control group (n=7). The treatment pigs were vaccinated with the PRRS-MLV and then divided into three groups<br>based on different diet types containing different soybean oils: (A) 5% fresh oil, (B) 5% heated oil for 43 h, and (C) 5%<br>heated oil for 38 h. The control pigs were not vaccinated and consumed (A) diet. Blood samples were collected for PRRS<br>immune response and for measuring oxidative status. No significant differences were observed among groups in<br>malondialdehyde (MDA), superoxide dismutase-1 (SOD-1), ELISA titer, and SN antibodies against PRRS virus.<br>Notably, the percentage of interferon-gamma (IFN-</span><span class="fontstyle2"></span><span class="fontstyle0">) producing cell increased significantly in group A in comparison<br>to that in the other groups on D28 and D56. In contrast, the percentage of interleukin-10 (IL-10) producing cell was<br>highest in group C, followed by group B and group A, respectively. Moreover, group C exhibited a higher number of<br>IL-10 producing cells compared to group A on D56 (</span><span class="fontstyle3">p</span><span class="fontstyle0">=0.082). Oxidized soybean oil exerts a negative effect on the cellmediated immune response to PRRS-MLV, especially in pigs fed oil containing high peroxide value and high numbers<br>of total polar compounds. These findings suggest that pig farmers should be more concerned with the quality of oil<br>used in the diet for nursery pigs.</span> </p>}, number={3}, journal={The Thai Journal of Veterinary Medicine}, author={Boonsoongnern, Alongkot and Jirawattanapong, Pichai and Surachetpong, Win and Boonsoongnern, Prapassorn and Poolperm, Pariwat}, year={2019}, month={Nov.}, pages={265–271} }