@article{Choisunirachon_Klansnoh_Phoomvuthisarn_Pisamai_Thanaboonnipat_Rungsipipat_2019, title={The expression of serum lactate dehydrogenase in canine oral tumors}, volume={49}, url={https://he01.tci-thaijo.org/index.php/tjvm/article/view/230631}, abstractNote={<p><span class="fontstyle0">Lactate dehydrogenase (LDH) has been reported to be a prognostic indicator of human malignant melanoma (MM),<br>lymphoma, renal cell carcinoma and prostate cancer. In veterinary medicine, elevation of serum LDH has been reported<br>in canine lymphoma and mammary gland tumors. However, the expression of the LDH in oral tumor-bearing dogs<br>has not been elucidated. In this study, serum LDH levels were evaluated and compared between healthy dogs (control;<br>n = 20) and oral tumor-bearing dogs (n = 34). Half of the tumor-bearing dogs (17dogs) had oral MM, followed by 6<br>dogs with oral squamous cell carcinoma (SCC), 4 dogs with fibrosarcoma (FS), 3 dogs with benign epithelial tumors<br>(BET), and 1 dog each with osteosarcoma, lymphoma, histiocytoma and acanthomatous ameloblastoma. Serum LDH<br>was significantly higher in oral tumor-bearing dogs (</span><span class="fontstyle2">P </span><span class="fontstyle0">= 0.0006). Besides, serum LDH expression of MM, SCC and FS<br>was significantly higher than that of the control group (</span><span class="fontstyle2">P </span><span class="fontstyle0">= 0.0078, 0.0030 and 0.0022, respectively). The expression of<br>serum LDH did not significantly correlate with the location of the primary tumor or the clinical stage of the disease,<br>the clinical stage II revealed the highest expression of the LDH though. The results indicate that serum LDH might be<br>useful as an indicator for oral tumors but further study examining a larger number of patients with each tumor type<br>would be advantageous.</span> </p>}, number={3}, journal={The Thai Journal of Veterinary Medicine}, author={Choisunirachon, Nan and Klansnoh, Urapa and Phoomvuthisarn, Panrawee and Pisamai, Sirinun and Thanaboonnipat, Chutimon and Rungsipipat, Anudep}, year={2019}, month={Nov.}, pages={283–288} }