@article{Kittivanichkul_Choisunirachon_Soontornvipart_Malaivijitnond_2019, title={The potential use of phytoestrogen containing the herb, Pueraria mirifica, for bone healing in osteoporotic monkeys}, volume={48}, url={https://he01.tci-thaijo.org/index.php/tjvm/article/view/179806}, abstractNote={<p><span class="fontstyle0">Within the last decade, the positive effects of </span><span class="fontstyle2">Pueraria mirifica </span><span class="fontstyle0">on osteoporosis have been established in rats<br>and monkeys. However, the effect of </span><span class="fontstyle2">P. mirifica </span><span class="fontstyle0">on bone healing has not been elucidated. In this study, post-menopausal<br>osteoporotic monkeys were subjected to an iliac crest biopsy, divided into two groups (5 animals/group), and fed daily<br>with standard monkey diet alone (PMP0 group) or mixed with 1,000 mg/kg body weight of </span><span class="fontstyle2">P. mirifica </span><span class="fontstyle0">powder<br>(PMP1000 group) for 16 months. The progression of the bone healing was continuously assessed by X-ray radiography,<br>and three individuals from each group were selected for a computed tomographic (CT) scan at 0, 8 and 16 months. The<br>individual from each group that showed the greatest progression of bone healing, based upon the CT image, was<br>selected for a second biopsy of the right ilium after 16 months of treatment and histological changes determined. The<br>perimeter and area measured by the X-ray radiograph were significantly decreased earlier in the PMP1000 group<br>compared to the PMP0 group, and the significant differences of the perimeter between the groups were detected in<br>month 3, 6 and 8. The 3D-CT scan showed a progressive bone healing in one PMP1000 individual, while histological<br>examination indicated a lower number of fibrocartilage cells and a higher amount of new bone formation compared to<br>the PMP0 monkey. In conclusion, PMP treatment could accelerate the progression of bone fracture healing in naturally<br>postmenopausal osteoporotic monkeys, in addition to the previously reported amelioration of bone loss.</span> </p>}, number={4}, journal={The Thai Journal of Veterinary Medicine}, author={Kittivanichkul, Donlaporn and Choisunirachon, Nan and Soontornvipart, Kumpanart and Malaivijitnond, Suchinda}, year={2019}, month={Mar.}, pages={583–593} }