Susceptibility of Clostridium difficile Isolated from Healthy Captive Asian Elephants to Metronidazole and Vancomycin

Authors

  • Nattawooti Sthitmatee Department of Veterinary Bioscience and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Muang, Chiang Mai 50100
  • Thanya Warinrak Department of Veterinary Bioscience and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Muang, Chiang Mai 50100
  • Waroot Wongkalasin Department of Companion Animal and Wild Life Clinic, Faculty of Veterinary Medicine, Chiang Mai University, Muang, Chiang Mai 50100

Keywords:

captive Asian elephant, Clostridium difficile, metronidazole, MIC, vancomycin

Abstract

Susceptibility to metronidazole and vancomycin, drugs of choice for Clostridium difficile infection, of 15 C. difficile isolates from 6 healthy Asian elephants was determined. All of the isolates belonged to only 1 ribotype pattern and carried both toxin A and B genes. The Minimal inhibitory concentration range of metronidazole and vancomycin, drugs of choice for treatment of C. difficile infection, was 0.125-4.0 μg/ml and 0.125-2.0 μg/ml, respectively. Moreover, MIC50 and MIC90 for metronidazole were 0.75 and 1.5 μg/ml while vancomycin was 1.0 and 2.0 μg/ml. There was no evidence of resistance to these antimicrobials. These results might be a preliminary data for further study of animal C. difficile.

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How to Cite

Sthitmatee, N., Warinrak, T., & Wongkalasin, W. (2013). Susceptibility of Clostridium difficile Isolated from Healthy Captive Asian Elephants to Metronidazole and Vancomycin. The Thai Journal of Veterinary Medicine, 43(2), 313–316. Retrieved from https://he01.tci-thaijo.org/index.php/tjvm/article/view/9776

Issue

Vol. 43 No. 2 (2013): June

Section

Short Communications