Evaluation of antimicrobial peptide K9CATH in a murine model of mastitis

Authors

  • Alberto Barreras-Serrano
  • Alma Rossana Tamayo-Sosa
  • Víctor Manuel del Villar-Pérez
  • Alma Angelina Castellanos-Félix
  • Gilberto López-Valencia
  • Luis Tinoco-Gracia
  • Rogelio Hernández- Pando
  • Tonatiuh Melgarejo

Keywords:

murine mastitis, K9CATH, antimicrobial peptide, Staphylococcus aureus

Abstract

In the present study the effect of antimicrobial peptide K9CATH was evaluated in a murine model of mastitis by Staphylococcus aureus. Mastitis was induced with a clinical isolate of S. aureus in 20 female Balb/c mice at 7 to 10 days of lactation. Ten mice (treatment group) received daily intramammary infusions of 32 μg/50 μL K9CATH peptide, for 3 consecutive days, and 10 other mice (control group) received only 50 μL of saline solution. Results showed a significant reduction (P0.01) in S. aureus CFU counts in the treatment group compared to the control group. These data suggest that the K9CATH peptide could be a potential candidate for the treatment of bovine mastitis.

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How to Cite

Barreras-Serrano, A., Tamayo-Sosa, A. R., Villar-Pérez, V. M. del, Castellanos-Félix, A. A., López-Valencia, G., Tinoco-Gracia, L., Hernández- Pando, R., & Melgarejo, T. (2017). Evaluation of antimicrobial peptide K9CATH in a murine model of mastitis. The Thai Journal of Veterinary Medicine, 47(2), 279–284. Retrieved from https://he01.tci-thaijo.org/index.php/tjvm/article/view/90290

Issue

Vol. 47 No. 2 (2017): June

Section

Short Communications