Expression of miR-29a and IFN- in pigs vaccinated with modified live PRRS vaccine

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the important RNA viruses that affects swine production worldwide. To better improve vaccine efficacy, understanding the molecular mechanisms and viral-host interaction is important to increase the knowledge of vaccine response. The objective of this study was to investigate the expression levels of miR-29a and IFN- in pigs that received modified live PRRSV vaccine. The study revealed that both miR-29a and IFN- transcript levels increased in vivo early, at day 3 post vaccination, whereas levels of miR-29a and IFN- mRNA were not different at day 7 post vaccination. Our study is the first attempt to demonstrate the level of this miR-29a in response to PRRSV vaccination. However, the molecular mechanisms of miR-29a and its functional role during PRRSV infection require further investigation.