Treatment outcomes of canine nasal tumor irradiation

Abstract

This study aimed to determine the treatment response of canine nasal tumor treated with only linear accelerated radiation therapy (LINAC) using volumetric measurement criteria at Kasetsart University Veterinary Teaching Hospital between May 2013 and August 2015. Medical records of the patients including age, breed, sex, histopathological diagnosis, clinical stage, types of radiation therapy and complications of treatment were recorded. All 20 dogs were irradiated with total dose ranging from 36 to 54 Gray (Gy). Computed tomography was performed with all dogs before and three months after treatment in order to evaluate tumor volume change. Results revealed that median survival time for all dogs was 383 days (95%CI 214.69-551.31) and median progression free was 384 days (95%CI 240.94-527.06). Considering tumor volume change, six dogs (30%) were classified as partial response at 3 months after radiation therapy, while 14 dogs (70%) were classified as stable disease. In addition, considering variables associated with survival time analyzed by log-rank test, it was found that age and volumetric measurement response correlated with survival time statistically significantly (P<0.05).