Comparison of Modified Warm Water Infusion and Air Insufflation for Colonoscopy in A Rat Colon Cancer Model

Abstract

Our aim is to compare the effect of warm water infusion and air infusion enteroscopy on the success rate of colonoscopy in a rat model of colorectal cancer. 60 rats with colorectal cancer were divided into 2 groups: the air infusion (AI) group taking air infusion enteroscopy and the warm water infusion (WWI) group taking warm water infusion enteroscopy. The success rate, testing time, pain score and diagnostic value of these two groups were evaluated. There are significant differences between two groups concerning the success rate and the average test time. In the WWI group, the success rate is 83.33% (25/30), and the average test time is 12.2±4.7 min, while in the AI group, the success rate is 56.67% (17/30), and the average test time is 17.6±5.8 min. Obvious lighter pain was observed in the WWI group than that of the AI group which reflected by pain score in the WWI group (1.7±0.8) compared with that of AI group (2.5±1.1) (p＜0.05). There is no significant difference in the success rate of the colorectal cancer model in the WWI group (90.00%, 27/30) and the AI group (93.33%, 28/30). No significant differences were observed in sensitivity, specificity, correct diagnosis index, and misdiagnosis rate between two groups. Warm water infusion enteroscopy can increase the success rate of colonoscopy while reducing the testing time, and give less pain during colonoscopy than the air infusion enteroscopy.