Efficacy of Intraarticular Administration of Hyaluronic Acid in Osteoarthritis After Surgical Correction of Canine Cranial Cruciate Ligament Rupture

Abstract

Canine osteoarthritis is a common disease in clinical practice. Causes of canine osteoarthritis are obscure. At present, nutraceuticals and hyaluronic acid are used for the treatment of canine osteoarthritis. This study assessed the efficacy of intraarticular administration of hyaluronic acid on the treatment of canine osteoarthritis. After undergoing surgical correction of cranial cruciate ligament rupture, 16 dogs were divided into 2 groups, HA and control groups. The dogs in the HA group (n=8) received intraarticular injection of hyaluronic acid. The control group (n=8) did not receive hyaluronic acid treatment after surgery. Lameness score, weight bearing score, radiographic examination and serum OA biomarker (WF6) were used for analysis. Results revealed that the HA group had better lameness score and weight bearing score, but there was no statistic difference in the radiographic finding and the levels of serum WF6 after 8 weeks of treatment.