The Safety Evaluation of Permethrin on Dogs When Used in a Prophylactic Dose for Ectoparasite Infection, by Measuring Serum Cholinesterase Activity

Abstract

The safety of permethrin at a prophylactic dose for ectoparasite infection in dogs was evaluated by the measurement of cholinesterase activity (ChE). On day 0, eight healthy dogs were exposed to spot - on formulation of permethrin. The results of serum ChE activity in all the dogs which measured on day 1 and 4 after exposure to permethrin showed no significant different comparing to those before exposure. There were no clinical signs in all dogs throughout the experiment. The result suggests that using spot-on formulation of permethrin at a prophylactic dose for ectoparasite infection is safe in dogs.