Effects of Permethrin at a Prophylactic Dose for Ectoparasite Infection on Cholinesterase Activity in Dogs

Abstract

Effects of permethrin at a prophylactic dose for ectoparasite infection on cholinesterase (ChE) activity was evaluated. Eight healthy dogs were exposed to a spot-on formulation of permethrin on day 0. The results of serum ChE activity in all of the dogs which was measured at 24 h after exposure to permethrin significantly decreased when compared to those before exposure. However, the serum ChE activity in all the dogs which was measured at 36 and 96 h after exposure to permethrin showed no significant difference as compared to those before exposure. There were no clinical signs in all dogs throughout the experiment. The results suggest that using spot-on formulation of permethrin at a prophylactic dose for ectoparasite infection is safe in dogs.