Blood Pressure, Urinary Protein Creatinine Ratio and Oxidative Stress in Dogs with Urolithiasis

Abstract

Blood pressure, urinary protein creatinine (UPC) ratio and oxidative stress (plasma melondialdehyde, urinary melondialdehyde creatinine ratio; UMDA/Cr, the activities of red blood cell catalase; RBC-CAT and red blood cell glutathione) were studied in 42 dogs with urolithiasis and 14 control healthy dogs. The types and location of calculi were defined. The results showed that calculi preferentially found in male and female dogs were calcium
oxalate and struvite, respectively. In female, calculi found mostly at urinary bladder while in male, they could be found in either urinary bladder and/or urethra. Dogs with urolithiasis were normotensive. However, UPC ratio was higher significantly (p<0.001) compared with control dogs. The BUN and plasma creatinine concentrations were elevated in dogs with urolithiasis only if the obstruction occurred especially in dogs with renal calculi. Dogs with
urate urolith had lower BUN compared with control dogs (p<0.05). There were no significant changes in oxidative stress parameters among each type of urolith except lower red blood cell catalase activity in calcium oxalate urolith (p<0.01). The significant positive relationships between UMDA/Cr and either UPC ratio (p<0.01) or plasma creatinine
concentration (p<0.05) were found. The results suggest that the oxidative stress may occur only in dog with calcium oxalate urolith. The renal oxidative damage which was represented by UMDA/Cr could be elevated when renal impairment was developed.