The development history of Germfree animal model and its application in the study of microbiota-related diseases

Abstract

A germ-free animal is an experimental animal with no live microorganisms and parasites in its body. It is a powerful experimental tool for the study of the relationship between microbiota and host health. We reviewed the development history of germ-free animals and provide an overview of their application in medical research, such as intestinal microbiota, immunology and oncology. We provide references for research on microbe-related diseases.