Dynamics and evolution of genotype 1 porcine reproductive and respiratory syndrome virus following its introduction into a herd concurrently infected with genotypes 1 and 2

  • Thitima Tripipat
  • Kepalee Saeng-chuto
  • Adthakorn Madapong
  • Christopher James Stott
  • Angkana Tantituvanont
  • Pavita Kaewprommal
  • Jittima Piriyapongsa
  • Dachrit Nilubol
Keywords: Porcine, PRRSV, Genotype 1, Evolution, Thailand

Abstract

This study was conducted to investigate the dynamics and evolution of porcine reproductive and respiratory syndrome virus (PRRSV) genotype 1 following its introduction into a herd concurrently infected with both PRRSV genotypes. The results demonstrated that 2 novel genotype 1 groups emerged, termed clusters II and III. The emergence of cluster II suggested that this cluster of genotype 1 virus potentially correlated with the outbreak. Then, cluster III was detected with the disappearance of cluster II. The evolution of the genotype 1 virus from cluster II to cluster III is likely to be associated with immune evasion induced by amino acid substitutions at N-linked glycosylation sites. In contrast, evolution of the genotype 2 isolates was not observed. This result suggests that genotype 2 viruses were not affected by the emergence of the genotype 1 virus and each genotype developed independently.

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Published
2021-06-07
How to Cite
Tripipat, T., Saeng-chuto, K., Madapong, A., Stott, C. J., Tantituvanont, A., Kaewprommal, P., Piriyapongsa, J., & Nilubol, D. (2021). Dynamics and evolution of genotype 1 porcine reproductive and respiratory syndrome virus following its introduction into a herd concurrently infected with genotypes 1 and 2. he hai ournal of eterinary edicine, 51(3), 519-529. etrieved from https://he01.tci-thaijo.org/index.php/tjvm/article/view/250768
Section
Original Articles