Evaluation of tear quantity and quality treated with gintonin eye drops in Labrador retrievers and English springer spaniels

  • Ji-seung Choi
  • Joon-Young Kim
  • Soon-wuk Jeong
Keywords: Gintonin, Schirmer tear test-1, Tear film break-up time, Tear osmolarity, Tear film quality

Abstract

The aims of this study were to determine the relationship between tear osmolarity (TO), Schirmer tear test-1 (STT-
1) and tear film break-up time (TBUT) values in canines and to determine the impact of eye drops containing gintonin
- a ginseng-derived lysophosphatidic acid (LPA) receptor ligand - on these indices. Fourteen canines (four English
springer spaniels and ten Labrador retrievers) were randomized into two groups: the control group received only
placebo eye drops (carboxymethylcellulose), while the experimental group received carboxymethylcellulose eye drops
containing 5 µg of gintonin. Treatment was applied twice per day for a period of four weeks and STT-1, TBUT and TO
were evaluated both prior to and following the treatment period; the latter using I-PEN® VET (I-MED Animal Health,
QC, Canada). Pearson's correlation coefficients were calculated to investigate potential associations between baseline
TO, STT-1 and TBUT values. Within-group statistical significance of value changes induced by treatment was
determined using Student’s t-test. Positive correlations exist between TO and STT-1 values, as well as between TO and
TBUT values (P = 0.001 and P = 0.032, respectively). Gintonin treatment significantly increased only TBUT (21.0 ± 11.2
s versus 7.5 ± 2.8 s) and TO (317.1 ± 18.1 mOsm/L versus 302.2 ± 19.3 mOsm/L) values (P < 0.01 and P < 0.05,
respectively). The results suggest that gintonin improves canine tear film quality, as indicated by increased TBUT and
TO values.

Downloads

Download data is not yet available.
Published
2021-01-08
How to Cite
Choi, J.- seung, Kim, J.-Y., & Jeong, S.- wuk. (2021). Evaluation of tear quantity and quality treated with gintonin eye drops in Labrador retrievers and English springer spaniels. he hai ournal of eterinary edicine, 51(1), 15-20. etrieved from https://he01.tci-thaijo.org/index.php/tjvm/article/view/247164
Section
Original Articles