Cardiac myxoma in the pulmonary trunk of a canine: presence of mesenchymal stem-like cells

  • Luis Alfaro
  • Alexis Enciso
  • Javier Enciso
Keywords: canine cardiac myxoma, mesenchymal tumor, mesenchymal stem-like cells

Abstract

Cardiac myxoma is a rare disease in dogs. Its histogenic origin has not yet been established, but the involvement of
mesenchymal stem cells has been suggested in humans. Here we report an encapsulated and benign cardiac myxoma
located at the entrance to the pulmonary trunk of the heart of an 8-year-old male Yorkshire Terrier dog presenting
sudden death in the absence of clinical symptoms related to cardiac alterations. Hematoxylin/eosin staining
demonstrated the mixoid origin of the myxoma, showing abundant hypocellular stroma with polygonal cells, while
immunohistochemistry (IHC) corroborated its mesenchymal lineage with the detection of vimentin and α-SMA
positive cell populations. In addition, IHC showed some cell populations in the stroma to be immunoreactive to the
pluripotency markers Oct4 and ALDH1. In conclusion, this is the first report of the presence of mesenchymal stem-like
cells with an Oct4 and ALDH1-positive IHC profile in a canine cardiac myxoma.

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Published
2020-09-01
How to Cite
Alfaro, L., Enciso, A., & Enciso, J. (2020). Cardiac myxoma in the pulmonary trunk of a canine: presence of mesenchymal stem-like cells. he hai ournal of eterinary edicine, 50(3), 431-434. etrieved from https://he01.tci-thaijo.org/index.php/tjvm/article/view/245853
Section
Short Communications