Pharmacokinetics of enrofloxacin in meat pigeons after a single intramuscular and oral administration


  • Xun Wang
  • Fei Shi
  • Yuhong Gou
  • Qiong Jiang
  • Jie Gong
  • Huaqiao Tang
  • Gang Ye
  • Chen Fang
  • Yinlun Li
  • Ling Zhao


Enrofloxacin, Pigeon, Pharmacokinetics, Intramuscular and oral administration


The pharmacokinetic properties of enrofloxacin were investigated after a single intra-muscular (i.m.) and oral
administration of 10 mg/kg b.w. to 12 healthy adult pigeons. Twelve pigeons were randomly divided to two groups.
Blood samples were collected at different time points following drug administration. Plasma enrofloxacin
concentrations were determined by reverse-phase high-performance liquid chromatography. Pharmacokinetic analysis
was conducted using non-compartmental methods via the ncappc package in R. The mean concentration area under
curve (AUC last) for enrofloxacin was determined to be 21.75±5.67 μg·h/mL for i.m., administration and
17.30±4.94μg·h/mL for oral administration. The elimination half- life (T1/2λz ) was 9.51±5.72 and 6.87±1.81 h for the i.m.,
and oral route, respectively. The mean maximum plasma concentration (Cmax) after i.m., administration was 2.50±0.27
μg/mL at 0.67±0.20 h, whereas after oral administration Cmax was 0.98±0.45μg/mL at 6.33±2.66 h. Mean residence time
(MRT last ) following i.m., injection was 11.02±2.28 and 14.85±1.78 h after oral administration. There are some
discrepancies in part of the pharmacokinetics parameters of enrofloxacin between meat pigeons and other poultry.




How to Cite

Wang, X. ., Shi, F. ., Gou, Y. ., Jiang, Q. ., Gong, J. ., Tang, H. ., Ye, G. ., Fang, C. ., Li, Y. ., & Zhao, L. . (2020). Pharmacokinetics of enrofloxacin in meat pigeons after a single intramuscular and oral administration. The Thai Journal of Veterinary Medicine, 50(2), 261–264. Retrieved from



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