Comparison of plasma-lyte A and trometamol-balanced priming solutions for cardiopulmonary bypass in a swine model: a pilot study

Abstract

Currently, the optimal priming solution for cardiopulmonary bypass (CPB) remains debatable. However, plasmalyte A solution (PLAS) has been widely used in the United States and is considered to be the standard priming solution
worldwide. Therefore, we designed a trometamol-balanced solution (Resculyte® solution, RS) to evaluate the safety
and feasibility for its use as a priming solution during CPB compared to PLAS. In total, 8 white pigs that underwent
CPB were assigned 1:1 to PLAS and RS groups. Hemodynamic parameters were recorded using an Abbott i-STAT
analyzer with CG4+ (for pH, pressure of carbon dioxide, pressure of oxygen , total carbon dioxide, bicarbonate, base
excess, oxygen saturation, and lactate), CG6+ (for sodium, potassium, chloride, blood glucose, blood urea nitrogen,
hematocrit, and hemoglobin), and cardiac troponin I (cTnI) cartridges during and after CPB. The parameters of
chemistries, electrolytes, and blood gas exhibited similar trends and revealed no considerable changes during and after
CPB. However, the pH values of the RS group remained stable compared with the PLAS group. Moreover, the cTnI
levels of the RS group were lower than those of the PLAS group, particularly on day 2. In conclusion, RS was a safe and
feasible priming solution in this pilot study during CPB. Future study will increase the data of swine models with CPB
to assess the clinical practice of RS compared to PLAS.