Occurrence of oral shedding of retroperitoneal fibromatosisassociated herpesvirus and lymphocryptovirus in free-ranging macaques, Thailand
Keywords:Gammaherpesvirus, Free-ranging macaque, Lymphocryptovirus, Retroperitoneal fibromatosis-associated herpesvirus
Oropharyngeal swabs of 262 free-ranging macaques (Macaca fasicularis and M. mulatta) were tested for Herpesviridae.
The occurrence was 24.4% (64/262), and no macaques showed clinical signs of the disease. The virus was restricted to
the northern and north-eastern regions of Thailand. DNA polymerase genes of the 64 positive samples were then
characterized and analyzed. Eight samples (3.1%) were found to be closely related to retroperitoneal fibromatosisassociated herpesvirus (RFHV) and were classified in the genus Rhadinovirus, subfamily Gammaherpesvirinae. The
phylogram of the virus revealed it to be species-specific within the macaque population. A total of 56 samples (21.4%)
exhibited a nucleotide relationship with lymphocryptovirus (LCV) in the genus Lymphocryptovirus, subfamily
Gammaherpesvirinae. The gender of the macaques did not significantly correlate with gammaherpesvirus infection. Our
results indicate that LCV is endemic in the macaque population in Thailand, but RFHV is not endemic.