Detection of transforming growth factor beta 1 in normal dogs and dogs with degenerative mitral valve disease

Authors

  • Wiyada Winyuchonharoen
  • Somporn Techangamsuwan
  • Sirilak Disatian Surachetpong

Keywords:

canine, degenerative mitral valve disease, mitral valve, plasma, transforming growth factor beta 1

Abstract

Degenerative mitral valve disease (DMVD) is a common finding of acquired heart diseases in small and
medium-sized adult dogs. Transforming growth factor beta 1 (TGF-β1) was found to increase in valves of DMVD dogs.
However, plasma TGF-β1 concentrations in dogs with DMVD have not been evaluated before. The objective of the
present study was to compare the plasma concentration of TGF-β1 between normal dogs and dogs with DMVD by
using an ELISA technique. This measurement might help to distinguish dogs with DMVD from healthy dogs. The
Mann-Whitney U test was used to compare plasma TGF-β1 concentrations between the two groups. A p-value less than
0.05 was considered statistically significant. Results showed no statistical difference (p=0.574) between the median
plasma TGF-β1 concentrations of 22 normal dogs (1.14, range 0.94-1.33 ng/ml) and 27 DMVD dogs (1.21, range 0.92-
1.32 ng/ml). In conclusion, the concentration of TGF-β1 is very low in the circulation; it may not be a suitable marker
for the diagnosis of DMVD due to its sensitivity.

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Published

2018-08-03

How to Cite

Winyuchonharoen, W., Techangamsuwan, S., & Surachetpong, S. D. (2018). Detection of transforming growth factor beta 1 in normal dogs and dogs with degenerative mitral valve disease. The Thai Journal of Veterinary Medicine, 48(2), 289–294. Retrieved from https://he01.tci-thaijo.org/index.php/tjvm/article/view/137882

Issue

Section

Short Communications