Avian Influenza Virus (H5N1) Inactivation by Binary Ethylenimine

Authors

  • Chatchai Sarachai Department of Food Animal Clinic, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100
  • Jiroj Sasipreeyajan Avian Health Research Unit, Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330,
  • Niwat Chansiripornchai Avian Health Research Unit, Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330,

Keywords:

avian influenza virus subtype H5N1, binary ethylenimine, hemagglutination activity, virus inactivation

Abstract

Avian influenza virus (AIV) subtype H5N1 is known as a highly pathogenic agent for man and various kinds of animals, especially avian species. Herein, AIV H5N1 was inactivated by binary ethylenimine (BEI), an aziridine compound, produced from 2-bromoethylamine hydrobromide. BEI was used at concentrations of 0.001 and 0.01 M for AIV inactivation. At the lower concentration (0.001 M), AIV could be inactivated within 24 hr. At the
higher concentration (0.01 M), AIV could be inactivated within 6 hr. After inactivation, no hemagglutination activity had been found meaning that AIV had been completely inactivated.

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How to Cite

Sarachai, C., Sasipreeyajan, J., & Chansiripornchai, N. (2013). Avian Influenza Virus (H5N1) Inactivation by Binary Ethylenimine. The Thai Journal of Veterinary Medicine, 40(1), 41–46. Retrieved from https://he01.tci-thaijo.org/index.php/tjvm/article/view/12326

Issue

Vol. 40 No. 1 (2010): March

Section

Original Articles