Endoscopic Evaluation of Gastric Mucosa to Determine Safety of Three Chondroprotective Drugs in Healthy Dogs

Authors

  • Korakot Nganvongpanit Animal Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100 Materials Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200
  • Kittipong Kungprathum Small Animal Hospital, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50200
  • Terdsak Yano Department of Food Animals, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100
  • Kumpanart Soontornvipart Department of Veterinary Surgery, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330

Keywords:

chondroitin sulfate, diacerein, dog, gastric mucosa, glucosamine

Abstract

This randomized, double-blind, placebo-controlled study investigated the effects of glucosamine/chondroitin sulfate, chondroitin sulfate, and diacerein on the gastric mucosa of dogs, and on clinical signs of vomiting and diarrhea. Twenty-one healthy adult dogs were included in the study, and were randomly assigned to seven treatment groups, 3 dogs per group. The effect of those medicines on the gastric mucosa was
evaluated by endoscopy on day 3 and day 14, and compared with pre-treatment. Clinical signs, including vomiting and diarrhea, were recorded every day during the study period. The results showed a non-significant effect of glucosamine/chondroitin sulfate, chondroitin sulfate, and diacerein on gastric mucosal lesions in healthy dogs. One
dog vomited after receiving glucosamine/chondroitin sulfate, but only for the first 2 days. All dogs receiving diacerein showed symptoms of diarrhea during the 14-day trial. In conclusion, glucosamine/chondroitin sulfate,
chondroitin sulfate, and diacerein at doses of 1,500 and 3,000 mg/day are gastric-safe for use in dogs.

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How to Cite

Nganvongpanit, K., Kungprathum, K., Yano, T., & Soontornvipart, K. (2013). Endoscopic Evaluation of Gastric Mucosa to Determine Safety of Three Chondroprotective Drugs in Healthy Dogs. The Thai Journal of Veterinary Medicine, 43(3), 439–443. Retrieved from https://he01.tci-thaijo.org/index.php/tjvm/article/view/12281

Issue

Vol. 43 No. 3 (2013): SEPTEMBER

Section

Short Communications