Patients with Melioidotic septic arthritis in Nakhonphanom Hospital

Authors

  • Montree Kiatchanon

Keywords:

septic arthritis, melioidosis

Abstract

           Objective: To study the demographic pattern, clinical characteristics, laboratory, treatment, outcome , and length of stay in patients with melioidotic septic arthritis.

            Materials and methods: This study was a retrospective study to review patients with melioidotic septic arthritis at Nakhonphanom Hospital between 1 October 2016 and                30 September 2021. The data were analyzed by frequency, percentage, mean , and standard deviation.

           Results: A total of 32 patients showed that the male to female ratio was 1.38: 1. The mean age was 56.62+12.72 years. The most of them were farmers 29 cases (90.62%). The most common predisposing condition was diabetic Mellitus 29 cases (90.62%). Duration before reaching hospital was 1-7 days (68.75%), average 8.45+6.24 days. All of them presented with fever, pain ,and swelling (100.00%). The most common site of infection was the knee joint 15 cases (46.87%), followed by the shoulder 6 cases (18.75%), the elbow 5 cases (15.62%), the hip 4 cases (12.80%), the wrist and the ankle was 1 case (3.12%). The diagnosis was made on the basis of the positive culture of burkholderia pseudomallei, Hemocultures were positive in 21 cases (65.62%), and synovial fluids were positive in 17 cases (53.12%), in six patients positive from blood as well as synovial fluid. Treatment included antibiotic therapy with arthrotomy 22 cases (68.75%). The mortality rate was 15.62 percent (5 cases). Length of stay 11.11+5.4 days.

         Conclusion: The diagnosis was made on the basis of the positive culture of burkholderia pseudomallei. Treatment as septicemic melioidosis for patients with severe septic arthritis , and  risk factors until proven that it is not.

References

Limmathurotsakul D, Wongratanacheewins S, Teerawattanasook N, Wongsuwan G,

Chisuksant S, Chaowagul W. Day NP, Peacoclc SJ, Increasing incidence of human

melioidosis in Northeast Thailand. Am J Trop Med Hyg 2010;82(6):1113-7.

Department of disease control. Annual Epidemiological Surveillance Report 2019.

(Internet online) 2020 (Cited 2022 Nov2). Available from: URL:

http://www.ddc.morph.go.th.

Morse LP, Smith J, Mehta J, Ward L, Cheng AC, Currie BJ. Osteomyelitis and septic arthritis

from infection with Burkhoderia pseudomallei: a20-year prospective melioidosis study from northern Australia. J orthop 2013;10:86-91.

Kumar VJ, Deepali J, Himanshu K, Ajay S, Kumar RA, Deepak M. Melioidosis: A review of

orthopaedic manifestation, Clinical features, diagnosis and management. Ind J Med Sci 2007; 61:580-7.

Currie BJ, Jacups SP, Cheng AC, Fisher DA, Anstey NM, Huffam SE, Krause VL. Melioidosis epidemiology and risk factors from a prospective whole population study in northern Australia. Trop Med Int Health, 2014;9:1167-74.

Nadeem Saijad Raja, Christine Scarbrook. Burkholderi Pseudomallei Causing Bone and

Joint infections: A Clinical Update. Infect Dis ther 2016;5:17-29.

Shetty RP, Mathew M, Smith J, Morse LP, Metha JA, Currie BJ. Management of melioidosis

osteomyelitis and septic arthritis. The Bone & Joint Journal 2015;97(2):277-82.

Moorthy S, Nagarajan K, Udahaya Sankar R, Gopal R, Yuvarajan S, Vignesh R, Venkatesh R, Ambroise MJ. Melioidosis Presenting As Septic Arthitis. JMSCR 2020; 8(1): 154-6.

Morse LP, Smith J, Mehta J, Ward L, Cheng AC, Currie BJ. Osteomyelitis and septic arthritis

from infection with Burkholderia pseudomallei: A 20-year prospective melioidosis study

from northern Australia. J Orthop. 2013;10(2):86-91.

Wu H, Wang X, Zhou X, Chen S, Mai W, Huang H, et al. Osteomyelitis and Septic Arthritis

Due to Burkholderia pseudomallei: A 10-Year Retrospective Melioidosis Study From South

China. Front Cell Infect Microbiol. 2021;11:654745.

Morgan DS, Fisher D, Marianos A, Curries BJ. An 18 year clinical review of septic arthritis from tropical Australia. Epidemiol Infect. 2006; 117(3): 423-8.

Kosuwon W, Taimglang T, Sirichativapee W, Jeeravipoolvarn P. Melioidotic septic arthritis

and its risk factors. J Bone Joint Surg Am. 2003;85(6):1058-61.

Teparrukkul P, Nilsakul J, Dunachie S, Limmathurotsakul D. Clinical Epidemiology of Septic

Arthritis Caused by Burkholderia pseudomallei and Other Bacterial Pathogens in Northeast

Thailand. Am J Trop Med Hyg. 2017;97(6):1695-1701.

Somkid surachai. Septic Arthitis at Nakhonphanom Hospital. Udonthani Hospital Medical

Journal 2018; 26(1): 64-73.

Peerawat Boonyateerana. Clinical characteristicis of Musculoskeletal Involvement in

Melioidotic Patients in Sawanpracharak Hospital. Sawanpracharak Medical Journal 2014; 11(1):24-41.

ภัทรพงษ์ พีรวงศ์. ปัจจัยที่มีความสัมพันธ์ต่อการตายของผู้ป่วยติดเชื้อเมลิออยโดสิสในกระแสเลือด ในโรงพยาบาลบุรีรัมย์. วารสารการแพทย์โรงพยาบาลศรีสะเกษ สุรินทร์ บุรีรัมย์ 2548; 20(3): 11-26.

Suputtamongkol Y, Hall AJ, Dance DA, Chaowagul W, Rajchanuvong A,Smith MD, White NJ.

The epidemiology of melioidosis in Ubon Ratchatani, northeast Thailand. Int J Epidemiol.

;23(5):1082-90.

Currie B. Melioidosis evolving concepts in epidemiology, pathogenesis, and treatment. Semin Respir Critical Care Med 2015;36:111-25.

Sookpranee M, Boonma P, Bhuripanyo K. Melioidosis at Srinagarind Hospital. In: Pungagupata S. Srisanthana T, Stapatayvong B. melioidosis: Proceeding of National workshop on

melioidosis. Bangkok: Bangkok Medical Publisher; 1987.

Pinyok Srisansanee. Clinical features and Factors Associated with mortality of naïve

Pyogenic arthritis patients In surin hospital. Medical Journal of Seisaket Surin Buriram

Hospital 2021; 36(2): 465-73.

Chote Pawasuttikul. Comparison of Needle Aspiration and Arthrotomy treatment for septic knee Arthritis: a10-Year retrospective study. JRCOST 2013;37(24):29-33.

สิทธิ ชัยบุตร. ผลลัพธ์การรักษาข้อเข่าอักเสบติดเชื้อด้วยวิธีการเจาะดูดจากข้อ เปรียบเทียบการผ่าตัดเปิดล้างข้อในโรงพยาบาลชัยภูมิ. ชัยภูมิเวชสาร 2014;34(2):40-8.

รอยพิมพ์ โสภาพงษ์. การศึกษาเมลิออยโดสิสในโรงพยาบาลยโสธร. ยโสธรเวชสาร 2565; 24(2): 68-86.

Churuangsuk C, Chusri S, Hortiwakul T, Charernmak B, Silpapojakul K. Characteristics, clinical outcomes and factors influencing mortality of patients with melioidosis in southern Thailand: A 10-year retrospective study. Asian Pac J Trop Med. 2016;9(3):256-60.

ชวยศ หาญหิรัญ. ปัจจัยที่ส่งผลทำให้ผลการรักษาเมลิออยโดสิสล้มเหลวในโรงพยาบาลเพ็ญ จังหวัดอุดรธานี. วารสารการแพทย์ โรงพยาบาลอุดรธานี 2564; 29(3): 346-5

Downloads

Published

2023-12-18

How to Cite

1.
Kiatchanon M. Patients with Melioidotic septic arthritis in Nakhonphanom Hospital. Nakhonphanom Hosp J [internet]. 2023 Dec. 18 [cited 2025 Dec. 10];10(3):e267730. available from: https://he01.tci-thaijo.org/index.php/nkpjournal_9/article/view/267730

Issue

Section

Original article