อัตราการเสียชีวิตและปัจจัยเสี่ยงที่สัมพันธ์กับการเสียชีวิตของทารกที่มีภาวะสูดสำลักขี้เทาในโรงพยาบาลปทุมธานี

บทคัดย่อ

Title: Mortality rate and risk factors among newborn infants with meconium aspiration syndrome in the Pathum Thani Hospital

Author: Pacharawee Sinwatanapanich, M.D.

Abstract

Objective: To study the mortality rates and risk factors associated with meconium aspiration syndrome among newborn infants in the Pathum Thani Hospital.

Methods: This retrospective study was conducted on newborn infants with meconium aspiration syndrome at the Pathum Thani Hospital. Data were collected from the medical records and the Chi-square test, Independent t-test, and Mann-Whitney U test were applied for the analysis. Moreover, multivariate logistic regression was used to reveal the relationship between the maternal factors, antenatal factors, infant and postnatal factors, and the mortality rate. The level of statistical significance was set at 0.05.

Results: Of 19,831 live births from 2016 to 2021 in the hospital, 180 were newborns with meconium aspiration syndrome of which 21 were dead (11.7%), and 3 cases were referred. The factors significantly contributing to newborn infant mortality in the study were the high quantity of meconium in amniotic fluid, gestational period < 37 or > 40 weeks, APGAR score < 7 at 10 min, persistent pulmonary hypertension, and intubation ≥ 2 days.

Conclusion: The mortality of newborn infants with meconium aspiration syndrome in the study was associated with a high quantity of meconium in amniotic fluid, gestational age less than 37 weeks or more than 40 weeks, APGAR score < 7 at 10 min, persistent pulmonary hypertension, and intubation ≥ 2 days.

Keywords: incidence, mortality rate, infants with meconium aspiration syndrome, Pathum Thani Hospital