ผลลัพธ์และอัตราการเกิดภาวะแทรกซ้อนของการให้ยา Ibuprofen  ในการรักษาทารกเกิดก่อนกำหนดที่มีภาวะ PDA ในโรงพยาบาลนครพนม

Thanyalak Ngaecharoenkul

Authors

Thanyalak Ngaecharoenkul

Keywords:

patent ductus arteriosus, preterm infant, ibuprofen

Abstract

Objectives: To study the outcome and incidence of complications of Ibuprofen administration in the treatment of preterm infants with PDA in the neonatal intensive care unit, Nakhon Phanom Hospital and to study incidence of PDA among all preterm infants in Nakhon Phanom Hospital.

Materials& Methods: A retrospective descriptive study cohort of all preterm infants diagnosed with PDA and ibuprofen treated in the neonatal intensive care unit, Nakhon Phanom Hospital from January 1^st, 2018 to December 31^st, 2021 by collecting and analyzing data, including general information and basic patient information. Patient's symptoms the effectiveness of the treatment including short-term complications after treatment (during the hospital stay)

Results: The incidence of PDA in preterm infants was 5.2%. Ibuprofen had 87.5% efficacy in PDA closure. 27.0% adverse effect was observed and no mortality from Ibuprofen was observed in PDA patients.

Conclusion: Ibuprofen treatment was 87.5 percentage effective, with few and mild side effects and no mortality from ibuprofen was found in PDA patients.

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