@article{Raruenrom_Theerakulpisut_Wannasarnmetha_2021, title={Prevalence and Significance of FDG-avid Mediastinal Lymph Nodes in Patients with Colorectal Cancer in a Tuberculosis-endemic Area}, volume={40}, url={https://he01.tci-thaijo.org/index.php/jhsmr/article/view/255386}, DOI={10.31584/jhsmr.2021833}, abstractNote={<p style="font-weight: 400;"><strong>Objective:</strong> To find prevalence and causes of fluorodeoxyglucose (FDG)-avid mediastinal lymph nodes in patients with colorectal cancer in a tuberculosis-endemic area.</p> <p style="font-weight: 400;"><strong>Material and Methods:</strong> For this study we enrolled patients with colorectal cancer who underwent Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT). Then, PET/CT images were reviewed by a nuclear medicine physician to find mediastinal lymph nodes with FDG uptake beyond the lung background defined as FDG-avid node. The degree of FDG uptake was graded and measured, and associated factors for presence of FDG-avid nodes were evaluated. The causes of FDG-avid nodes were also determined.</p> <p style="font-weight: 400;"><strong>Results:</strong> A total of 109 patients (64 males; mean age 61.2 years) were studied. Seventy-five patients had FDG-avid mediastinal nodes; accounting for a prevalence of 68.8% (95% CI: 59.2-77.3%). Most of the patients had multiple and bilateral nodes; with the zones of hilar and interlobar being the most common location. Age ≥50 years was the only associated factor for FDG-avid nodes (OR of 3.16, p-value=0.035). Only one out of the 32 patients (with fulfilled followup criteria) had a metastatic node.</p> <p style="font-weight: 400;"><strong>Conclusion:</strong> The prevalence of FDG-avid mediastinal nodes in colorectal cancer patients in a tuberculosis-endemic area was significantly high. Most of the lesions were benign in nature; thus, interpretation of these findings should be considered carefully to avoid false-positive results.</p>}, number={3}, journal={Journal of Health Science and Medical Research}, author={Raruenrom, Yutapong and Theerakulpisut, Daris and Wannasarnmetha, Mix}, year={2021}, month={Sep.}, pages={261–270} }