Imidazoline Receptor and Imidazolidine Derivatives

Abstract

Imidazoline receptors are new receptors, which are classified as non-adrenergic binding sites. These receptors provide a new concept in treating hypertensive without the sedative side effect. Many imidazolidine derivatives were synthesized and studied for their pharmacological activities. These compounds reduce pressure in the ocular tissue instead of the circulatory system. Structure activity relationship studies revealed that imidazole ring is essential for binding to the receptors and the side chain attached to the imidazole ring is important for the lowering intra-ocular pressure properties. Therefore, the imidazolidine derivatives can be useful as effective agents for treating glaucoma.