Anti-Plasmodial Activity of Bisbenzylisoquinoline Alkaloids from Michelia Figo Leaves

Authors

  • Ampai Phrutivorapongkul Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand
  • Chikara Ichino Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
  • Nijsiri Ruangrungsi Faculty of Pharmaceutical Sciences and Institute of Health Research, Chulalongkorn University, Bangkok, Thailand
  • Aki Ishiyama Research Center for Tropical Diseases, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan
  • Hitomi Sekiguchi Research Center for Tropical Diseases, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan
  • Miyuki Namatame Research Center for Tropical Diseases, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan
  • Hiroaki Kiyohara (1) Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan; (2) Oriental Medicine Research Center, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan
  • Kazuhiko Otoguro Research Center for Tropical Diseases, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan
  • Haruki Yamada (1) Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan; (2) Research Center for Tropical Diseases, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan; (3) Oriental Medicine Research Center, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan
  • Satoshi Omura (1) Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan; (2) Research Center for Tropical Diseases, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan

Keywords:

Michelia figo, bisbenzylisoquinoline alkaloid, anti-malarial, magnoline, magnolamine

Abstract

Two bioactive bisbenzylisoquinoline namely, magnoline (1) and magnolamine (2), were isolated from the leaves of Michelia figo Sprenge. These compounds possessed potent in vitro antimalarial activity both chloroquine-resistant (K1) and chloroquine-sensitive (FCR3) strains of Plasmodium falciparum. It is the first time for 2 to be reported this activity. Their structures were determined by spectroscopic methods and by comparison of previous reports.

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Published

2019-04-13

How to Cite

Phrutivorapongkul, A., Ichino, C., Ruangrungsi, N., Ishiyama, A., Sekiguchi, H., Namatame, M., Kiyohara, H., Otoguro, K., Yamada, H., & Omura, S. (2019). Anti-Plasmodial Activity of Bisbenzylisoquinoline Alkaloids from Michelia Figo Leaves. Journal of Health Research, 20(2), 121–128. Retrieved from https://he01.tci-thaijo.org/index.php/jhealthres/article/view/184970

Issue

Vol. 20 No. 2: September 2006

Section

ORIGINAL RESEARCH ARTICLE