Associated factors of hepatitis C infection in pregnant women at Outpatient Department of Peoples Medical University and Hospital District Shaeed Benazir Abad, Sindh province, Pakistan

Authors

  • Akhlaque Hussain Magsi College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand
  • Sathirakorn Pongpanich College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand

Keywords:

Hepatitis C virus, Pregnant women, Pakistan

Abstract

Purpose - This study aimed to explore the risk factors associated with transmission of hepatitis C virus (HCV) in pregnant women attending clinics at Peoples Medical College & Hospital in Shaheed Benazir Abad province, Pakistan.

Design/methodology/approach - A descriptive cross-sectional study was conducted among 318 pregnant women, aged from 16 to 45 years, who visited in the Department of Gynecology and Obstetrics during May to June 2018. Irrespective of gestational age on their first visit of antenatal care were also recruited. A structured questionnaire was used to interview participants using convenient sampling.  Descriptive statistic was employed for the data analysis. 

Findings - Out of 318 respondents, 26 (8.2%) were reported positive with HCV. Socio-demographic factors and past medical history were significantly associated with no education 10 (38.5%), injection 24 (92.3%), and blood transfusion 15 (57.7%).

Originality/value - HCV is a common infection in pregnant women. The prevalence of HCV was associated with socio-demographic factors including poor literacy rate, low socio-economic status, past medical history. Unsafe injection and blood transfusion were found to be strongly associated with increased of HCV among the pregnant women.

References

1. Rustgi VK. Drug hepatotoxicity. Clin Liver Dis. 2017; 21(1): i. doi: 10.1016/S1089-3261(16)30094-0

2. da Silva EP. Genomic integration of hepatitis C virus fragments in the European rabbit and Lepus europaeus: Detection and characterization. Portigal: Universidade do Porto; 2016.

3. Ghany MG, Strader DB, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis C: An update. Hepatology. 2009 Apr; 49(4): 1335-74. doi: 10.1002/hep.22759

4. Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013 Apr; 57(4): 1333-42. doi: 10.1002/hep.26141

5. Arshad M, El-Kamary SS, Jhaveri R. Hepatitis C virus infection during pregnancy and the newborn period--are they opportunities for treatment? J Viral Hepat. 2011 Apr; 18(4): 229-36. doi: 10.1111/j.1365-2893.2010.01413.x

6. Koblinsky MA. Beyond maternal mortality--magnitude, interrelationship, and consequences of women's health, pregnancy-related complications and nutritional status on pregnancy outcomes. Int J Gynaecol Obstet. 1995 Jun; 48(Suppl): S21-32.

7. Luby SP, Qamruddin K, Shah AA, Omair A, Pahsa O, Khan AJ, et al. The relationship between therapeutic injections and high prevalence of hepatitis C infection in Hafizabad, Pakistan. Epidemiol Infect. 1997 Dec; 119(3): 349-56.

8. Aceijas C, Stimson GV, Hickman M, Rhodes T. Global overview of injecting drug use and HIV infection among injecting drug users. Aids. 2004 Nov; 18(17): 2295-303.

9. Umar M, Bushra HT, Ahmad M, Data A, Ahmad M, Khurram M, et al. Hepatitis C in Pakistan: a review of available data. Hepat Mon. 2010 Summer; 10(3): 205-14.

10. Waheed Y, Shafi T, Safi SZ, Qadri I. Hepatitis C virus in Pakistan: A systematic review of prevalence, genotypes and risk factors. World J Gastroenterol. 2009 Dec; 15(45): 5647-53.

11. Umer M, Iqbal M. Hepatitis C virus prevalence and genotype distribution in Pakistan: Comprehensive review of recent data. World J Gastroenterol. 2016 Jan; 22(4): 1684-700. doi: 10.3748/wjg.v22.i4.1684

12. Akhtar AM, Khan MA, Ijaz T, Maqbool A, Iqbal Z, Rehman A, et al. Hepatitis C virus infection in pregnant women in Lahore, Pakistan: An analytical cross sectional study. International Journal of Agriculture and Biology. 2014; 16(1): 160-4.

13. Muzaffar F, Hussain I, Haroon TS. Hepatitis C: The dermatologic profile. Journal of Pakistan Association of Dermatologists. 2008; 18(3): 171-81.

14. Al-Kubaisy WA, Niazi AD. Socio-demographic characteristics as risk factors for hepatitis C virus infection among pregnant women in Iraq. J Womens Health Issues Care. 2013; 2(2). doi: 10.4172/2325-9795.1000106

15. Umumararungu E, Ntaganda F, Kagira J, Maina N. Prevalence of hepatitis C virus infection and its risk factors among patients attending Rwanda Military Hospital, Rwanda. Biomed Res Int. 2017; 2017: 5841272. doi: 10.1155/2017/5841272

16. Attaullah S, Khan S, Khan J. Trend of transfusion transmitted infections frequency in blood donors: provide a road map for its prevention and control. J Transl Med. 2012 Jan; 10: 20. doi: 10.1186/1479-5876-10-20

17. Rehman AU. Adoption of WHO standard operating procedures for blood screening in hospitals of Islamabad, Pakistan. Afr J Pharm Pharmacol. 2011; 5(22): 2479-82. doi: 10.5897/AJPP11.584

18. Bibi S, Dars S, Ashfaq S, Ara Qazi R, Akhund S. Seroprevalence and risk factors for hepatitis C virus (HCV) infection in pregnant women attending public sector tertiary care hospital in Hyderabad Sindh. Pak J Med Sci. 2013 Apr; 29(2): 505-8.

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Published

2018-12-28

How to Cite

Magsi, A. H., & Pongpanich, S. (2018). Associated factors of hepatitis C infection in pregnant women at Outpatient Department of Peoples Medical University and Hospital District Shaeed Benazir Abad, Sindh province, Pakistan. Journal of Health Research, 32(Suppl.2), S246-S256. Retrieved from https://he01.tci-thaijo.org/index.php/jhealthres/article/view/168537

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