Effect of Aloe Vera and Wax Gourd Extracts in Reducing Burning Sensation of Capsicum Gel

Abstract

The aim of this research was to develop a capsicum analgesic gel with a reduced burning sensation. The study started by determining a suitable vehicle with optimal proportions. The soothing substances, aqueous extracts of aloe vera and wax gourd, were used with a formulary concentration of 0.0125% capsaicin. A clinical trial was conducted with 30 healthy volunteers to test the product’s efficacy. It was observed that after applying the capsicum analgesic gel the burning sensation started with itching, then flushing followed by burning. The maximum burning sensation was experienced at 30 min., after which time it gradually declined and finally dissipated at 480 min. The burning sensation when using capsicum gel with aloe vera and wax gourd was reduced by 21.49% and 36.25%, respectively. The concentration of soothing vehicle was correlated with the burning sensation while the burning sensation was related to the skin erythema with a correlation coefficient (R2) of 0.9584.