Acute Toxicity Test of Medicinal Plants and Herbal Remedies of Aphthous Ulcer

Authors

  • Rith Watthanachaiyingcharoen Faculty of Pharmacy, Srinakharinwirot University, Nakhonnayok, Thailand
  • Kantimanee Phanwichien Faculty of Sciences, Kasetsart University, Bangkok, Thailand
  • Apichat Pradermwong Faculty of Sciences, Mahidol University, Bangkok, Thailand
  • Narisa Kamkaen (1) Faculty of Pharmacy, Srinakharinwirot University, Nakhonnayok, Thailand; (2) Research and Development Institute, Suan Dusit Rajabhat University, Bangkok, Thailand

Keywords:

Aphthous ulcer, Quercus infectoria (FAGACEAE), Kaempferia galanga (ZINGIBERACEAE), Coptis chinensis (RANUNCULACEAE), Glycyrrhiza uralensis (LEGUMINOSAE), Toxicity test

Abstract

Four medicinal plants, Quercus infectoria (FAGACEAE), Kaempferia galanga (ZINGIBERACEAE), Coptis chinensis (RANUNCULACEAE) and Glycyrrhiza uralensis (LEGUMINOSAE), and two aphthous ulcer preparations with these plants were tested using the brine shrimp lethality test and in vivo acute toxicity (Wistar rat and Swiss albino mouse). In cytotoxicity test, Q. infectoria showed the highest toxicity at LD50 8.82 μg/ml (24 h) and 6.26 μg/ml (48 h) compared with the other plants. In vivo test, the high dose of aphthous powder (2-8 g/kg) and apthhous gel (3-12 mg/kg) did not cause histopathologic effect on rodent liver and kidneys. The results suggest that these plants and their preparations should be safe for the human ulcer treatments.

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Published

2018-11-21

How to Cite

Watthanachaiyingcharoen, R., Phanwichien, K., Pradermwong, A., & Kamkaen, N. (2018). Acute Toxicity Test of Medicinal Plants and Herbal Remedies of Aphthous Ulcer. Journal of Health Research, 23(4), 169–174. Retrieved from https://he01.tci-thaijo.org/index.php/jhealthres/article/view/156531

Issue

Vol. 23 No. 4: October - December 2009

Section

ORIGINAL RESEARCH ARTICLE