Antityrosinase and Antibacterial Activities of Mangosteen Pericarp Extract

Abstract

The objective of this study is to determine the tyrosinase inhibition and antibacterial activities against the pathogenic bacteria in the oral cavity of the mangosteen pericarp extract. The results showed that the mangosteen pericarp extract inhibited the tyrosinase enzyme at IC50 = 67 ng/ml. Furthermore, the mangosteen pericarp extract also exhibited the antibacterial activities against the pathogenic bacteria in the oral cavity, Streptococcus mutans DMST18777, Porphyromonas gingivalis DMST2136, and Streptococcus pyogenes DMST17020 at minimal inhibitory concentration (MIC) of 0.01 mg/ml, and Staphylococcus aureus ATCC25923 at MIC of 0.1 mg/ml by agar dilution method.