Study on Genetic Polymorphisms of Heme Oxygenase-1 in Different Ethnic Groups of Malaria Patients

Authors

  • Jiraporn Kuesap Pharmacology and Toxicology Unit, Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand
  • Kenji Hirayama Department of Molecular Immunogenetics, Institute of Tropical Medicine, Nagasaki University, Japan
  • Mihoko Kikuchi Department of Molecular Immunogenetics, Institute of Tropical Medicine, Nagasaki University, Japan
  • Ronnatrai Ruangweerayut Mae Sot General Hospital, Tak Province, Thailand
  • Kesara Na-Bangchang Pharmacology and Toxicology Unit, Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand

Keywords:

heme oxygenase, malaria, Plasmodium falciparum

Abstract

The study in genetic polymorphism of heme oxygenase-1 (HO-1) in different ethnic groups of malaria patients, we analyzed the frequencies of (GT)n alleles in a total of 200 Thai, Burmese and Karen patients. In Thai patients, the frequencies of short (21-27), medium (28-33) and long (34-39) (GT)n repeats of HO-1 gene were 89 (50.6%), 75 (42.6%), and 12 (6.8%), respectively. The corresponding values observed in Burmese patients were 82 (45.0%), 84 (46.2%), and 16 (8.8%), whereas that in Karen patients were 24 (57.1%), 12 (28.6%), 6 (14.3%), respectively. The SL genotype of Thais was significantly different from Burmeses. This finding may suggest that difference in the expression of HO-1 genotype in different ethnic groups may associate to malaria disease.

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Published

2018-11-16

How to Cite

Kuesap, J., Hirayama, K., Kikuchi, M., Ruangweerayut, R., & Na-Bangchang, K. (2018). Study on Genetic Polymorphisms of Heme Oxygenase-1 in Different Ethnic Groups of Malaria Patients. Journal of Health Research, 22(2), 105–108. Retrieved from https://he01.tci-thaijo.org/index.php/jhealthres/article/view/155617

Issue

Vol. 22 No. 2: April-June 2008

Section

SHORT REPORT