α-Glucosidase Inhibitory Activity of Thai Mimosaceous Plant Extracts

Abstract

Twenty species of Thai plants in Mimosaceae family were exhausively extracted with petroleum ether, dichloromethane and ethanol respectively. The plant extracts were studied for their α-glucosidase inhibition activity by spectrophotometry using 1-deoxynojirimycin as a positive control. The result showed that most percentage yields of the plants were in ethanol extract. Entada rheedii seed coat, Archidendron jiringa seed coat, Albizia lebbeck branch bark, Parkia speciosa pericarp and Albizia lebbeckoides bark exhibited very high inhibition with IC50 of 0.0043, 0.0054, 0.0397, 0.0581 and 0.0702 mg/ml respectively. Moreover, the stem, leaves, branch and bark of Xylia xylocarpa also displayed high α-glucosidase inhibitory activity. The most fractions that showed the promising activity are 95 % ethanolic extracts. It is of interest that these species should be further studied for the treatment diabetes mellitus (type II) as the glucosidase inhibitor and the lowering of blood glucose level.