Association of ageing and PCOS women’s metabolic turbulence: A cohort study in hospitals of Faisalabad, Pakistan

Abstract

Background: Ethno-demographic data on polycystic ovary syndrome (PCOS) is still prone to contentious debate since heterogeneity amid PCOS women of different regions.
Objective: To study the impacts of ageing on endocrinopathy of metabolic disorders (MetS) among PCOS women and cardiovascular risk (CVR).
Methods: In the current study, PCOS women (n = 500) with age range of 15 - 45 years were recruited from Faisalabad region of Pakistan and their reproductive history with brief demographic data were recorded through interview questionnaire while medical assessments were carried out under protocol. Following categorization of five age groups, statistical significance was determined through analyses of variance and regression analysis.
Results: Mean number of menstrual cycles per year, luteinizing hormone: follicle stimulating hormone ratio, hirsutism score declined significantly with advancing age of PCOS women (P < 0.05). While unprecedented age related progression was ensued in cycles’ duration, bleeding days after menarche onsets, polycystic ovary morphology (PCOM) components including ovarian volume, diameter and number of follicles. Among PCOS women with MetS, mean fasting blood glucose and waist to hip circumference ratio, body mass index, and blood pressures were examined the highest in older women but inverse relationship of high density lipoprotein (HDL) was noticed with progressive age groups (P < 0.01). Reciprocal attenuation in stillbirth and inflation in conception rate were also evident among progressive age groups accordingly. Similarly, Framingham points and CVR10 was significantly the highest (1.5%) among older age groups PCOS women with increasing age conformity (P < 0.05).
Conclusion: Ageing among PCOSs, unequivocally, exacerbated the endocrinopathy while synergetic metabolic abnormalities have transcended impacts on cardiovascular risks among older aged PCOS women.