Addison’s disease due to disseminated histoplasmosis: A case report

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Krittaya Rattanakorn
Ratchathorn Panchaprateep


Addison’s disease, also known as primary adrenal insufficiency, can manifest as generalized mucocutaneous hyperpigmentation. The common causes of Addison’s disease in developing countries are mycobacterium and fungal infections. Histoplasma capsulatum is a dimorphic fungi, which may disseminate to the adrenal glands and skin, causing Addison’s disease and skin lesions such as macules, acneiform pustular eruptions, erythematous papules, nodules, keratotic plaques with or without crust and mucosal ulceration.

We present a case of a 45-year-old male with Addisonian pigmentation for one year together with multiple skin-colored flat top papules on both inguinal areas 3 months earlier. Cutaneous lesions were carefully physical examined might easily lead to the cause of Addison’s disease by using biopsy from skin lesions which found histoplasma capsulatum same as found in fine needle aspiration (FNA) from right adrenal mass.

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Clinical report