Randomized placebo-controlled trial comparing efficacy of nonablative fractional photothermolysis combined with topical calcipotriol for the treatment of keloid and hypertrophic scar

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Marisa Pongprutthipan
Nattaporn Rojarayanont


Background : Nonablative fractional laser resurfacing has been shown to have size reduction effect on hypertrophic scar with minimal side effects; and antifibrotic effect of vitamin D in keloid fibroblasts has been reported in vitro. A combination of the two treatments should gain additional benefits from facilitation of wound healing, transdermal drug delivery and recurrence prevention.

Objectives : To evaluate the efficacy of nonablative fractional laser resurfacing combined with topical calcipotriol for the treatment of keloid and hypertrophic scar.

Methods : Subjects were treated with six fractional 1,550 nm Ytterbium/Erbium: fiber laser treatment weekly for entire lesion. Each lesion was randomly treated with topical calcipotriol or white petrolatum twice daily. Follow-up visits were done at week 6th and 12th. Clinical appraisal achieved by Patient and Observer Scar Assessment Scale (POSAS) and evaluator blinded photographic clinical assessment.

Results : Twelve subjects completed treatments in the study. Mean POSAS showed significant reduction (P <0.05) at week 6 but no statistical difference between groups was observed. Photographic clinical assessment had mild
(1 - 25%) to moderate (26 - 50%) improvement in majority of the cases but there was no statistical difference between groups.

Conclusion : Nonablative fractional laser is an effective treatment for keloids and hypertrophic scars while the benefit of topical calcipotriol could not be demonstrated in the study.

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