Effect of smoking on endothelial function and arterial stiffness in Thai subjects

Abstract

Background : Smoking is an important risk factor for cardiovascular diseases. In vasculature, smoking cause endothelial dysfunction and arterial stiffness. However, the effects of cigarette smoking on endothelial function and arterial stiffness in Thai subjects have not been studied.

Objectives : To evaluate endothelial function and arterial stiffness of Thai smoking volunteers.

Methods : The eligible participants were 72 healthy subjects, aged 20 - 60 years old. The subjects were divided into two groups, 36 non-smokers and 36 smokers. Endothelial function was evaluated by flow mediated dilatation
(FMD) of brachial artery and arterial stiffness was assessed by cardioankle vascular index (CAVI).

Results : FMD of smoking group was significantly lower than that of non-smoking group (P < 0.05) but CAVI and ankle brachial index (ABI) were not significantly different between non-smoking and smoking groups.

Conclusion : Function of endothelial cells decreases in smokers with low level of smoking. Therefore, assessment of endothelial function may be used as a screening test for smokers before development into atherosclerosis
and cardiovascular disease.