Chulalongkorn Medical Bulletin <p>ISSN: 2651-2149 (Print)<br>ISSN: 2672-9288 (Online)<br>Editor-in-Chief: Professor Sittisak Honsawek</p> <p>Chulalongkorn Medical Bulletin เป็นวารสารสาขาวิทยาศาสตร์และเทคโนโลยี มีวัตถุประสงค์<br>เพื่อเผยแพร่วิชาการแพทย์และศาสตร์ที่เกี่ยวข้องสัมพันธ์กับการแพทย์ โดยรับพิจารณาบทความภาษาไทย และภาษาอังกฤษ ประเภทนิพนธ์ต้นฉบับและบทความประเภทอื่น ๆ เพื่อให้สมาชิกและผู้อ่านได้รับประโยชน์อย่างเต็มที่ในการเพิ่มพูนความรู้ และประสบการณ์ให้ทันสมัย และคงมาตรฐานในการดำรงความเป็นแพทย์หรือวิชาชีพเฉพาะแห่งตน</p> <p>บทความที่ส่งมาต้องไม่เคยพิมพ์เผยแพร่มาก่อน อนึ่งกองบรรณาธิการขอสงวนสิทธิ์ในการตรวจทาน แก้ไขต้นฉบับและพิจารณาตีพิมพ์ ส่วนข้อคิดเห็นในบทความเป็นความเห็นและเป็นความรับผิดชอบของเจ้าของบทความโดยตรง บทความแต่ละบทความต้องผ่านการพิจารณาจากผู้ทรงคุณวุฒิที่ตรงตามสาขาของบทความนั้น อย่างน้อย 2 ท่าน และผู้ทรงคุณวุฒิต้องมาจากหน่วยงานที่ต่างกันกับผู้เขียน อีกทั้งชุดผู้ทรงคุณวุฒิที่ประเมินบทความเดียวกันนั้นจะต้องมาจากหน่วยงานที่ต่างกันด้วย ซึ่งจัดประเภทของการ Peer Review เป็นแบบ Double Blinded หมายถึง ผู้ทรงคุณวุฒิจะไม่ทราบชื่อผู้เขียน และผู้เขียนจะไม่ทราบชื่อผู้ทรงคุณวุฒิ</p> <p>Chulalongkorn Medical Bulletin มีกำหนดตีพิมพ์เผยแพร่ ปีละ 2 ฉบับ (ราย 6 เดือน) ฉบับที่ 1 มกราคม - มิถุนายน และฉบับที่ 2 กรกฎาคม - ธันวาคม</p> <p>&nbsp;</p> <h2><a href="">Online First</a></h2> <h3>Original article</h3> <h3>Review article</h3> <h3>Abstract</h3> <p align="justify">- ย่อวารสาร</p> Faculty of Medicine, Chulalongkorn University en-US Chulalongkorn Medical Bulletin 2651-2149 Effects of aromatherapy treatments on dream of addictive substance: 9-sided feelings and quality of sleep in amphetamine users <p>Background: The use of amphetamines for a long time affects the mind, especially thoughts, feelings, and dreams. Therefore, the goal of experimental research using by aroma therapy was to assess feelings and dream of patients with amphetamine.</p> <p>Objective: To study the effect of aromatherapy therapy on dream of addictive substance: 9-sided feelings and quality of sleep to amphetamine users.</p> <p>Methods: Aromatherapy (jasmine oil) before bed 1 hour consecutive 7 nights was provided to participants. Data were collected from 20 female patients. Self-report included, namely:<br>1) General background</p> <p>2) Visual Analog scale of Feelings 9-side (VAS)</p> <p>3) Dream Record about drugs, and</p> <p>4) Sleep Quality Assessment (PSQI).</p> <p>Results: Most subjects used drugs in the age range of 13 - 20 years. Most of them used amphetamines 95%, cigarettes and tobacco 70%. Score of 9-sides feelings, dreams record about drugs and quality of sleep on the day of receiving the essential oil was lower than the date of receiving the essential oil.</p> <p>Conclusion: These findings resulted in the changes in the mood and feelings of the subjects. This suggested that aromatherapy therapy could be developed to guide the treatment of patients with amphatamine.</p> Chanida Rojchomnong Atapol Sughondhabirom Patraporn Kinnon Copyright (c) 2019-09-12 2019-09-12 2 1 3 14 Prevalence and associated factors of premenstrual syndrome and premenstrual dysphoric disorder among psychiatric outpatients with mood and anxiety disorders <p>Background: Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are theoretically common comorbidities of mood and anxiety disorders. However, there are only few studies directly examine the prevalence of PMS and PMDD among patients with mood and anxiety disorders in Thailand.</p> <p>Objectives: To examine the prevalence and associated factors of PMS and PMDD among psychiatric outpatients with mood and anxiety disorders.</p> <p>Methods: Data were collected from 200 female psychiatric patients aged 18 - 45 years who were diagnosed with mood or anxiety disorders at the Psychiatric Outpatient Clinic, King Chulalongkorn Memorial Hospital during March to August 2015. The questionnaires included, namely;</p> <p>(1) demographic information;</p> <p>(2) life styles information (e.g. diet and exercise);</p> <p>(3) medical and menstrual information; and,</p> <p>4) Premenstrual Symptoms Screening Tool (PSST) - Thai version.</p> <p>Results: According to PSST, the prevalence of PMS and PMDD were 47.5 % and 13.0%, respectively. From logistic regression analysis, PMS was significantly associated with chocolate consumption (<em>P</em> &lt; 0.01), no banana consumption (<em>P</em> &lt; 0.05), weight change (<em>P</em> &lt; 0.05), menstrual irregularity (<em>P</em> &lt; 0.05), dysmenorhea (<em>P</em> &lt; 0.05), myalgia (<em>P</em> &lt; 0.01) and benzodiazepines use (<em>P</em> &lt; 0.05), whereas PMDD was significantly associated with financial inadequacy (<em>P</em> &lt; 0.05), chocolate consumption (<em>P</em> &lt; 0.01), no banana consumption (<em>P</em> &lt; 0.05), abnormal length of<br>menstrual cycle (<em>P</em> &lt; 0.05), and dizziness during menstrual period (<em>P</em> &lt; 0.05).</p> <p>Conclusion: PMS and PMDD are common in mood and anxiety disorders. Focusing on PMS and PMDD in these patients is necessary for appropriate treatment and improvement in quality of care.</p> Natsara Dumrongpiwat Chutima Roomruangwong Copyright (c) 2019-09-12 2019-09-12 2 1 15 25 Self-esteem of parents and adverse childhood experiences <p>Background: Receiving an adverse experience of a child could have a long-term impact on the future, including potential effect on child rearing in many dimensions. Self-esteem is also one of the factors that may affect the efficiency of raising children. In Thailand, however, there has never been a study of the relationship between adverse childhood experience and self-esteem.</p> <p>Objectives: To study the relationship of the overall score of adverse childhood experiences and the self-esteem in parents who brought their children to receive treatment at the Child and Adolescent Psychiatric Department.</p> <p>Methods: The cross-sectional descriptive study conducted with 103 subjects recruited from parents visiting the Child and Adolescent Psychiatric Clinic, King Chulalongkorn Memorial Hospital, from February to May, 2018. The research questionnaire consisted of demographic data form, Adverse Childhood Experiences (ACE) Questionnaire, Thai-version and Rosenberg Self-Esteem (RSE) Questionnaire, Thai-version.</p> <p>Results: Personal factors such as having an underlying disease, psychiatric disorders and depression were significantly associated with the overall score of adverse childhood experiences significance. Personal factors such as having an immune deficiency disease and having a psychiatric disorder were significantly associated with self-esteem. The overall score of adverse childhood experiences is inversely related to self-esteem.</p> <p>Conclusion: The overall score of adverse childhood experiences is inversely related to self-esteem. The results of this study can be used for the planning of care for children and adolescent psychiatric patients. Furthermore, these could be used for the prevention of adverse experiences for the children in next generation.</p> Atchariya Aphiwatthanakul Parichawan Chandarasiri Copyright (c) 2019-09-12 2019-09-12 2 1 27 37 Relationships between health care behaviors, anxiety, social support and quality of life among pregnant women with pregnancy induced hypertension <p>Background: Pregnancy induced hypertension is a complication that has serious consequences in pregnant women and their fetus. It is a crisis that can affect the quality of life of pregnant women. Research on relationships between healthcare behaviors, anxiety, social support and quality of life in pregnant women with pregnancy induced hypertension will help to plan the improvement of the quality of life in women with pregnancy induced hypertension.</p> <p>Objectives: To study the quality of life and factors related to quality of life of pregnant women with pregnancy induced hypertension.</p> <p>Methods: This study was cross sectional research design. A total of 92 pregnant subjects with pregnancy induced hypertension were registered at the Antenatal Clinic, The Thai Red Cross Society. A convenience sampling was used to recruit the subject. Data were collected between March to May 2018. Questionnaires used to collect the data consist of demographic data, 12 Short Form Health Survey version 2 (SF-12 v.2), health care behaviors of pregnant women with hypertension, state anxiety inventory and multidimensional scale of perceived social support. Reliability were 0.84, 0.71, 0.91 and 0.86 respectively.</p> <p>Results: The results showed that the mean score of life quality was 64.10 (SD = 15.42) which is a good level. As for correlation analysis, anxiety was negatively related to the quality of life. (<em>r</em> = -0.545, <em>P</em> &lt; 0.01). However, health care behaviors and social support were not correlated with the quality of life of pregnant women with pregnancy induced hypertension. (<em>r</em> = 0.140, - 0.043, <em>P</em> &lt; 0.05).</p> <p>Conclusions: The findings indicated that anxiety was negatively related to the quality of life. Therefore, this study suggested that nurse should develop a nursing intervention to reduce anxiety in order to promote quality of life in pregnant women with pregnancy induced hypertension.</p> Duangporn Maitreechit Siriwan Sangin Supit Siriarunrat Copyright (c) 2019-09-12 2019-09-12 2 1 39 47 Type 2 diabetes mellitus and lifestyle: A systematic review <p>Background: Diabetes Mellitus (DM) is a chronic disease, common in people of all ages and both genders. The cause of type 2 DM is both genetic and lifestyle; whereas diabetes affects the quality of life of the patients. Therefore, the researchers are interested to find out the association between type 2 DM and lifestyle of the patients; the findings can be used for disease prevention and further research regarding type 2 DM and lifestyle in Thailand.</p> <p>Objective: This study is aimed to access the association of patients’ life style to type 2 DM and type 2 DM to patient’s life style.</p> <p>Methods: A systematic review search of databases that met eligibility criteria using PICOS model (Participant: DM type 2 patients; Intervention: DM type 2; Comparison: control group; Outcome: an association between disease and lifestyle; and, Study design: All designs) was conducted. Relevant data were obtained from PubMed during 2009 - 2014.</p> <p>Results: A total of 2,666 articles obtained, of which 44 articles met the eligibility criteria. The result demonstrates that Type 2 DM is associated with patient’s life style.</p> <p>Conclusion: The awareness of risk behaviors may help reduce the risk of type 2 DM. As for those with type 2 DM, good understanding about the disease and how to take care of themselves will enable them to control blood glucose level that can reduce complications for good quality of life.</p> Sineenart Chautrakarn Supalak Phonphithak Copyright (c) 2019-09-12 2019-09-12 2 1 49 59 Factors predicting recovery in patients with post total laparoscopic hysterectomy <p>Background: Recovery is the goal of health-care services that emphasizes on patient’s point of recovery in those who receive total laparoscopic hysterectomy to return to normal and active daily living and well-being. There are a number of factors involving the recovery which includes duration of pelvic pain of pre-operation, body mass index of pre-operation, patient’s ability post-operation, anxiety of the patient pre-operation, and knowledge of the patient about pre-operation.</p> <p>Objective: To identify predictive factors for recovery among patients with post total laparoscopic hysterectomy.</p> <p>Methods: A multi-stage sampling from 2 sectiondary hospitals, King Chulalongkorn Memorial Hospital and Rajavithi Hospital, recruited 109 subjects. Their data were collected using 7 questionnaires:<br>1) demographic data form;</p> <p>2) duration pelvic pain before operation;</p> <p>3) body mass index record;</p> <p>4) post-operation ability of the patient;</p> <p>5) hospital anxiety scale;</p> <p>6) knowledge about pre-operation; and</p> <p>7) quality of recovery. The data were analyzed using stepwise multiple-regression.</p> <p>Results: Recovery of patients with post total laparoscopic hysterectomy was of moderate level (17.36 <img title="\pm" src="\pm"> 3.09). Significant factors to recoveryamong patients with total laparoscopic hysterectomy were anxiety of pre-operation (beta = - 0.35), knowledge about pre-operation (beta = 0.41), ability of the patient post-operation (beta = 0.26) and body mass index of pre-operation (beta = - 0.25). However, duration pelvic pain of pre-operation was not significant factor. They could explan the 63.2% of recovery in patients with post total laparoscopic hysterectomy (<em>P</em> &lt; 0.05).</p> <p>Conclusion: This study promotes postoperative recovery in patients with post total laparoscopic hysterectomy.</p> Nongnapath Somthong Ratsiri Thato Copyright (c) 2019-09-12 2019-09-12 2 1 61 66 Outcomes and safety of parenteral nutrition in pediatric patients at King Chulalongkorn Memorial Hospital <p>Background: Parenteral nutrition (PN) is an essential treatment in pediatric patients who were critically ill or underweight. These patients are usually malnourished and needed nutritional assessment.</p> <p>Objectives: This study is aimed to evaluate outcomes and safety of parenteral nutrition in pediatric patients.</p> <p>Methods: All pediatric patients (0 - 18 years old) received total parenteral nutrition; 176 parenteral nutrition prescriptions and 56 medical records were analyzed, and retrospective descriptive studied. By using questionnaire with information of the patients and laboratory data, the data were collected for 6 month, and were analyzed by using statistics, percentage mean, and standard deviation.</p> <p>Results: The average age was 1.8 <span style="text-decoration: underline;">+</span> 5.2 days (49% male). The most cause for parenteral nutrition were preterm and low birth weight 17 case (30%). The mean duration of total parenteral nutrition (TPN) is 10.84 <span style="text-decoration: underline;">+</span> 7.5 days (range 2 - 35 days). The majority of infusion route was central line 37 cases (66%). 51 cases (91%) cases eventually received full enteral nutrition but 5 cases (9%) were expired. Among those who we had the data, 13% had increased BMI for age z-score after TPN therapy. Most patients had PN-related complications which occurred more than one type and more than once for each event. The most frequent were metabolic complications in 48 cases (86%); the common ones were metabolic acidosis 97 events (21%), hyperchloremia 96 events (21%), and hypokalemia 66 events (15%).</p> <p>Conclusion: The result of the study that most pediatric patients received total parenteral nutrition have nutritional status was unchanged. Secondly, having better nutrition and the most common complications are metabolic complications.</p> Suree Nimitwongsin Sopida Chansurai Achiraya Buddhanoy Nucha Amornrattanachareon Sirinuch Chomtho Copyright (c) 2019-09-12 2019-09-12 2 1 67 77 Presenteeism in medical residents <p>Recently, media coverage has led to an increase in recognition of presenteeism among health-care workers. Presenteeism is defined as employees presenting to work despite physical or mental illnesses that should be justified for sick leaves. It is especially prevalent among health care workers, social workers, welfare workers and teachers. Presenteeism can lead to negative economic impacts including reduction in productivity and quality of work. It can also have detrimental effects on the psychological health including exhaustion and burnout. In addition, presenteeism can also increase the spread of infectious diseases from health care workers to patients. In Europe, health care workers’ responses to questionnaires indicated that 50% up to 80% of them experienced presenteeism. Specifically, among medical residents the prevalence was 59.1%. Associated factors contributing to presenteeism included personal health resource, occupational health factor and personal characteristics. However, the prevalence and risk factors associated with presenteeism among Thai medical residents are very little. To be information for preventing related factors. Therefore, the purpose of this academic subject is to determine the size of problem and related factors with work while sick in the medical residents.</p> Vithawut Surawattanasakul Pornchai Sithisarankul Copyright (c) 2019-09-12 2019-09-12 2 1 79 85 Antibody screening and identification in transfusion medicine and benefits of antibody in development of human monoclonal hybridoma for blood group reagent production <p>Antibody against ABO blood group have been called naturally occurring antibody or regular antibody or expected antibody while other blood group system shows an unexpected antibody which is composed of alloantibody and autoantibody. Alloantibody does not respond against person’s red blood cells antigens. On the other hand, autoantibody does recognize red blood cells antigens.</p> <p>Antibody screening and identification are the main procedure before blood transfusion due to immediate or delayed hemolytic transfusion reactions (HTR) from antibody. Moreover, they are the cause of hemolytic disease of the fetus and newborn (HDFN) and shorter self-life of red blood cells.</p> <p>Plasma or serum including of single high-titer antibody shows benefits in the production of blood group typing reagents. Especially, B lymphocytes secret single antibody to make benefits in production of human monoclonal hybridoma for rare blood group reagents.</p> <p>This article need to compile many antibody screening and antibody to identify methods and exemplify interesting study reports of antibody screening and identification by using different methods of choice of medical scientist and medical technologists. Moreover, it will help them choose suitable methods and have some idea about how to make benefits from antibody in plasma and B lymphocytes secret antibody.</p> Siriporn Ponsen Nootchanat Premprayoon Udom Tingtoy Copyright (c) 2019-09-12 2019-09-12 2 1 87 96 Anti-Jka that are detected by solid-phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions <p>แอนติบอดีของหมู่เลือดระบบ Kidd มักเป็นสาเหตุของทั้ง acute และ delayed hemolytic transfusion reactions รายงานนี้เปรียบเทียบอัตราการตรวจพบ anti-Jka เมื่อใช้วิธี gel column agglutination กับวิธี solid-phase red blood cell adherence (SPRCA) โดยศึกษาข้อมูลการตรวจทางห้องปฏิบัติการย้อนหลัง พบว่ามีผู้ป่วย 17 รายมี anti-Jka หลังจากการให้เลือดแล้วเกิด hemolytic transfusion reactions โดยทั้ง 17 รายนี้ตรวจพบ anti-Jka ด้วยวิธี SPRCA แต่ตรวจไม่พบด้วยวิธี gel วิธีการศึกษางานวิจัยเป็นการรวบรวมข้อมูลการตรวจทางห้องปฏิบัติการย้อนหลัง แบ่งเป็น 3 ช่วงเวลา</p> Kallaya Kerdkaewngam Copyright (c) 2019-08-09 2019-08-09 2 1 97 97