Marchiafava-Bignami Disease: A Case Report and Role of Nursing


  • Thayuta Inkaew
  • Amphan Winiyom
  • Chujit Karach


Marchiafava-Bignami, Corpus Callosum, Alcohol


Marchiafava-Bignami Disease is a rare disease of the nervous system and is diagnosed through history taking and radiologic examination. The specific pathology of the brain is found in the Corpus Callosum and the factors associated with this disease include alcohol intake, vitamin deficiencies and nutrients. This paper presented a case of a 61-year-old Thai male alcoholic patient presented with alteration of conscious. The CT scan of the brain revealed hypodensity lesion of Corpus Callosum and subcortical white matter. He was admitted to a semi-intensive care unit. He responded to the treatment regimen including Vitamin B1, B1, 6, 12, steroid, folic acid and antiepileptic drug. The patient improved after receiving the treatments. Later, he was referred to a local hospital. According to the case study, nurses presented an important role in caring for patients during hospitalization and in preventing complications to ensure patient’s survival. In addition, for survivors, it is recommended that counseling on alcohol withdrawal, rehabilitation and nutrition education be given priority in order to provide patients with a better quality of life after surviving the disease.


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สรวิเชษฐ์ รัตนชัยวงศ์. (2558). Wernicke-Korsakoff
syndrome. วารสารสมาคมประสาทวิทยาศาสตร์
ภาคตะวันออกเฉียงเหนือ, 10(2), 80-91.
อรวรรณ ศิลปกิจ. (2556). โรคจิตจากโรคมาเคียฟาวา-
บิคนามิ. วารสารสุขภาพจิตแห่งประเทศไทย,
21(3). 198-208.
Boutboul, D., Lidove, O., Aguilar, C., Klein, I., & Papo,
T. (2010). Marchiafava-Bignami disease
complicating SC hemoglobin disease and
Plasmodium falciparum infection. La Presse
Medicale, 39(9), 990-993.
Caulo, M., Briganti, C., Notturno, F., Committeri, G.,
Mattei, P. A., Tartaro, A., . . . & Uncini, A.
(2009). Non-alcoholic partially reversible
Marchiafava-Bignami disease: review and
relation with reversible Splenial lesions a case
report and literature review. The neuroradiology
journal, 22(1), 35-40.
Celik, Y., Temizoz, O., Genchellac, H., Cakir, B., &
Asil, T. (2007) A Non-Alcoholic Patient
with Acute Marchiafava-Bignami Disease
Associated with Gynecologic Malignancy:
Paraneoplastic Marchiafava-Bignami Disease?.
Clinical Neurology and Neurosurgery, 109(6),
505-508. Retrieved from
Consoli, A., Pirritano, D., Bosco, D., Postorino, P., &
Consoli, D. (2014). Corticosteroid treatment in
a patient with Marchiafava-Bignami disease.
Neurological Sciences, 35(7), 1143-1145.
Gambini, A., Falini, A., Moiola, L., Comi, G., & Scotti,
G. (2003). Marchiafava-Bignami disease:
longitudinal MR imaging and MR spectroscopy
study. American journal of neuroradiology,
24(2), 249-253.
Haas, L., Tjan, D., Van Die, J., Vos, A., & van Zanten,
A. (2006). Coma in an alcoholic: Marchiafava-
Bignami disease. The New Zealand Medical
Journal (Online), 119(1244).
Hammond, N., Wang, Y., Dinchkie, M., & Barohn, R.
(2013). Nutritional neuropathies. Neurologic
Clinics, 31(2), 477-489.
Heinrich, A., Runge, U., & Khaw, A. V. (2004).
Clinicoradiologic subtypes of Marchiafava-
Bignami disease. Journal of neurology, 251(9),
Hillbom, M., Saloheimo, P., Fujioka, S., Wszolek, Z.
K., Juvela, S., & Leone, M. A. (2013). Diagnosis
and management of Marchiafava–Bignami
disease: a review of CT/MRI confirmed cases.
Journal of Neurology, Neurosurgery &
Psychiatry, 85(2), 168-173.
Jorge, J. M., Gold, M., Sternman, D., Prabhakaran, K.,
& Yelon, J. (2015). Marchiafava-Bignami
disease in a trauma patient. Journal of
emergencies, trauma, and shock, 8(1), 52-54.
Jung, J. W., gun Hwang, I., Park, H. S., Koh, I. S., &
Kim, H. K. (2015). Rapid Recovery from
Marchiafava-Bignami Disease after Intravenous
Corticosteroid Administration. Journal of
Neurocritical Care, 8(1), 25-29.
Mogal, V., Mohammad, S., Rathi, A., & Seth, K. (2013).
Marchiafava-bignami disease- a case report
and a brief review of literature. International
Journal of Science and Research, 4(5), 3187-
Pasutharnchat, N., & Phanthumchinda, K. (2002).
Marchiafava-Bignami Disease: a care report.
Journal of The Medical Association of
Thailand, 85, 742-746.
Saraweera, D., Sundaram, V., & Saab, S. (2016).
Evaluation and management of hepatic
encephalopathy: current status and future
directions. Gut and Liver, 10(4), 509-519.
Suzuki, Y., Oishi, M., Ogawa, K., & Kamei, S. (2012).
A patient with Marchiafava–Bignami disease
as a complication of diabetes mellitus treated
effectively with cortico steroid. Journal of
Clinical Neuroscience, 19(5), 761-762.
Tekwani Parmanand, H. (2016). Marchiafava-Bignami
disease in chronic alcoholic patient. Radiology
Case Reports, 11(234), 234-237.
Wenz, H., Eisele, P., Artemis, D., F๖rster, A., &
Brockmann, M. A. (2014). Acute Marchiafava
Bignami disease with extensive diffusion
restriction and early recovery: case report
and review of the literature. Journal of
Neuroimaging, 24(4), 421-424.
Yadala, S., & Luo, J. J. (2013). Marchiafava-bignami
disease in a nonalcoholic diabetic patient.
Case Reports in Neurological Medicine, 2013.
Online publication. doi:
Zuccoli, G., Siddiqui, N., Cravo, I., Bailey, A., Gallucci,
M., & Harper, C. G. (2010). Neuroimaging
findings in alcohol-related encephalopathies.
American Journal of Roentgenology, 195(6),




How to Cite

Inkaew, T., Winiyom, A., & Karach, C. (2018). Marchiafava-Bignami Disease: A Case Report and Role of Nursing. Journal of Nursing and Health Sciences, 12(1), 1–10. Retrieved from