TY - JOUR AU - Chongcharoen, Patthamaphorn AU - Sassanarakkit, Supitcha PY - 2022/08/22 Y2 - 2024/03/28 TI - Defining Threshold Value of 50-g Glucose Challenge Test to Diagnose Gestational Diabetes Mellitus in At-risk Women JF - Lampang Medical Journal JA - Lampang Med J VL - 43 IS - 1 SE - Original Article DO - UR - https://he01.tci-thaijo.org/index.php/LMJ/article/view/253576 SP - 7-15 AB - <p><strong>Background:</strong> Gestational diabetes mellitus (GDM) is usually screened by the 50-g glucose challenge test (GCT) and subsequently confirmed its<br />diagnosis with the 100-g oral glucose tolerance test (100-g OGTT). The very-high glucose level obtained from the 50-g GCT test may be valid<br />to diagnose GDM and discard the unnecessary 100-g OGTT test.</p><p><strong>Objective:</strong> To define the threshold value of 50-g GCT using for diagnosis of GDM in the diabetic at-risk pregnant women.</p><p><strong>Materials and methods:</strong> A diagnostic research was conducted among 552 pregnant women who had ≥1 risk of GDM and received 50-g GCT<br />in Lampang Hospital between January 2019 and September 2021. In case of blood sugar ≥140 mg/dl, the 100-g OGTT was implemented and<br />interpreted according to Carpenter &amp; Coustan criteria to diagnose GDM. The results 50-g GCT were categorized with 10 mg/dL increment and<br />analyzed to define the cut-off value for GDM diagnosis.</p><p><strong>Results:</strong> The mean age was 31.0 years (SD 5.7) and 407 women (73.7%) were multigravida. Most of 50-g GCT performed at gestational age ≥24<br />weeks (64.3%). GDM were diagnosed in 178 cases (32.2%) with the 100-g OGTT using Carpenter &amp; Coustan criteria. At the cut-off value of 50-g GCT<br />≥210 mg/dl, GDM could be diagnosed in 100% of cases. Both specificity and positive predictive value were 100%.</p><p><strong>Conclusion:</strong> In pregnant woman who has at least 1 risk factor and blood level of 50-g GCT ≥210 mg/dl, diagnosis of GDM could be made without<br />confirmation by the 100-g OGTT.</p> ER -