@article{Jenjarat_Sittisomwong_Pattanittum_Rattanaphan_2022, title={Administration of Intravenous Dexamethasone for Prevention of Postoperative Swelling in Bilateral Sagittal Split Ramus Osteotomy Setback (BSSRO SETBACK) Patients: A Double-Blind, Randomized Controlled Trial}, volume={25}, url={https://he01.tci-thaijo.org/index.php/KDJ/article/view/248892}, abstractNote={<p>Dexamethasone is commonly used to reduce post-operative swelling in orthognathic surgery patients. However, the effective administration dose of dexamethasone is still controversial among studies. The objective of this study is to study the efficacy and side effects of different administration doses of intravenous dexamethasone on reducing post-operative swelling and serum C-reactive protein levels. 14 patients (2 male, 12 female, age 19-42 years) undergoing BSSRO setback surgery at Faculty of Dentistry, Khon Kaen University during May 2019 to December 2020 had participated in this study. 4 patients were randomized into the control group (no dexamethasone). 5 patients in the first study group received 8 mg of intravenous dexamethasone at 30-60 minutes pre-operatively and 3 times post-operatively (total dose 32 mg) and 5 patients in the second study group received 16 mg of intravenous dexamethasone at 30-60 minutes pre-operatively (total dose 16 mg). The facial measurement method was used to record post-operative swelling at 4 time points: pre-operative and 24 hours, 48 hours, and 14 days post-operatively. Side effects following dexamethasone administration were also collected. The study results showed that there was no statistical difference in facial swelling between both study groups and control group. Meanwhile, the C-reactive protein level in the 8-mg ×4 dexamethasone group was lower than the control group with statistical significance. None of the side effects was found in this study.</p>}, number={1}, journal={Khon Kaen University Dental Journal}, author={Jenjarat, Thanabhon and Sittisomwong, Siripong and Pattanittum , Porjai and Rattanaphan, Pattaramon}, year={2022}, month={Mar.}, pages={1–13} }