Efficacy and Safety of Ya Khiao-Hom Powder for the Treatment of Aphthous Ulcer

Main Article Content

Pattaraporn Chaihad
Nattakitta Pholor
Potchara Khamseetha
Subin Kongmuang
Krit Pongpirul
Methin Phadungkit


Ya Khiao-Hom Powder (KHP) is a Thai traditional medicine preparation in the National List of Essential
Medicines. The remedy has been used to relieve fever as well as the symptoms of aphthous ulcer. This quasiexperimental study aimed to evaluate the safety and efficacy of KHP for the treatment of aphthous ulcer and was conducted in 100 patients of Namphong Hospital. The subjects were equally divided into two groups. The experimental group received KHP 1 gram dissolved in 15 ml of warm water to be taken orally twice daily before meal in the morning and evening as well as the application of KHP over the ulcers 4 times daily after meal and at bedtime, while the subjects in the control group received 0.1% triamcinolone oral paste, apply as thin film cover the ulcers 3-4 times daily after meal and at bedtime. The sizes of the ulcers and pain scores were measured and recorded on days 0, 2 and 6. Overall satisfaction of the treatment and side effects were also recorded. The results showed that the mean ages of the experimental group and the control group were 53.1 years and 55.2 years, respectively. The number of oral ulcers in each subject in both groups was 1–3. On day 0, the mean ulcer size at the 1st position in the experimental group was significantly greater than that in the control group (p < 0.05), but those in the 2nd and 3rd positions were not significantly different (p ≥ 0.05), while on day 2, the mean ulcer size at all positions in the experimental group greatly reduced but was not significantly different from that in the control group (p ≥ 0.05). On day 6, all oral ulcers healed in all patients in the experimental group, while the healing rate in the control group was 74.0%. On days 2 and 6, the mean pain score in the experimental group was significantly lower than that in the control group (p < 0.05). In addition, no adverse effects were found. In conclusion, this study has shown that
KHP is effective for the treatment of aphthous ulcer without causing any side effect


Download data is not yet available.

Article Details

Original Articles


Subcommittee of Nationality List of Essential Medicines. Nationality List of Essential Medicines. A.D. 1999. Bangkok: Cooperative Printing House of Thailand; 2012. (in Thai)

Ada’s Medical Knowledge Team. Aphthous Mouth Ulcers. [Internet]. 2020 Feb [cited 2020 Dec 20]; Available

from: https://ada.com/conditions/aphthous-ulcers/

Sonpirom S. Outpatient database of Nam Phong Hospital (December 2016-May 2018). Khon Kaen: Nam Phong

Hospital; 2019. (in Thai)

Rungsiyanont S, Vacharotayangul P, Talungchit S. The survey of prevalence of aphthous oral ulceration by

patient’s self-report in 12-to 18-years old Thai students in Srinakharinwirot Prasarnmitr demonstration school.

SWU Dent J. 2010;3(1):7-14.

Archanupab S. General Disease Treatment Textbook 2: 350 diseases and maintenance and prevention. Bangkok: Holistic Publishing; 2010. (in Thai)

Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am.2014;58(2):281-97.

Femiano F, Lanza A, Buonaiuto C, Gombos F, Nunziata M, Piccolo S, Cirillo N. Guidelines for diagnosis and

management of aphthous stomatitis. Pediatr Infect Dis J. 2007;26(8):728-32.

Puangthong Kraiphibun. Aphthous ulcer. [Internet]. 2017 Jul. [cited 2019 Jun 20]; Available from: https://

qrgo.page.link/GwTMX (in Thai)

Altenburg A, Zouboulis CC. Current concepts in the treatment of recurrent aphthous stomatitis. skin therapy

Lett. 2008;13(7):1-4.

Altenburg A, Abdel-Naser MB, Seeber H, Abdallah M, Zouboulis CC. Practical aspects of management of recurrent aphthous stomatitis.J Eur Acad Dermatol Venereol. 2007;21(8):1019-26.

Panichayupakaranant P. Preparation of α-mangostin rich extract gel using for oral ulcer (alpha-mangostin)

[Internet]. 2015 Nov [cited 2019 May 24]; Available from: https://rdo.psu.ac.th/th/index.php/recommend/788-

alpha-mangostin. (in Thai)

Kitchanapanich B, Prucksunand C, Prucksunand K, Wimolwattanapun S. Comparison the treatment of aphthous ulcers by using turmeric in orabase to orabase as a control group (clinical trial phase III). Journal of Naval Medicine. 2001;38(1):32-47. (in Thai)