Systematic Review on Curcuma longa vs. Acarbose for Diabetes Mellitus Prevention in Patients with Impaired Fasting Glucose

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Thanawat Wongphan
Sermsiripoca Sermsiripoca
Krit Pongpirul
Duangkaew Panyaphu
Jitisak Poonsrisawat
Pratchayanan Poonniam
Phanupong Phutrakool
Jindaporn Puripattanavong


Introduction and objectives: Diabetes mellitus (DM) is one of the leading causes of mortality and morbidity
in Thailand. There are multiple methods for helping people to prevent DM such as lifestyle modification, modern drug medication, and herbal therapy. Turmeric (C. longa) extract, or curcumin, is one of the herbal remedies that can decrease the incidence of DM and cardiovascular disease like anti-diabetic drug acarbose. This study aimed to explore and compare the efficacy of curcumin and acarbose. Methodology: Systemic review was done according to the PRISMA protocol. Three databases were used, including PubMed®, Scopus® and Web of sciences®. Results: Totally, 115 publications were retrieved from the databases but only two were selected. The review found no direct efficacy comparison between curcumin and acarbose, but curcumin could decrease DM incidence by 16.4% and aided patients to decrease their BMI by 6.43%. Whereas, acarbose could decrease DM incidence to 32%; however, 25% of these patients dropped out of the trial. Discussion: Even though curcumin and acarbose are effective in decreasing new DM cases, acarbose showed a high dropout rate; and there have been no studies on the effect of curcumin on human blood vessels. So a complete comparison could not be undertaken. Conclusions: Both curcumin and acarbose have the potential to decrease DM incidence, but direct efficacy comparison is lacking.
Thus, comparative studies on this matter should be done in the future.


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