@article{Chanthawong_Paholpak_Junnamom_Subongkot_Patthanasetthanon_Boontawee_Shoora_Paholpak_2013, title={Drug Use Review of Olanzapine for Psychiatric Outpatients at Srinagarind Hospital}, volume={57}, url={https://he01.tci-thaijo.org/index.php/JPAT/article/view/5801}, abstractNote={<p><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><sub>ABSTRACT</sub></span></span></span></span></p><p><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><sub>Background: </sub></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><sub>Psychiatric disorders are common worldwide including Thailand. At present, olanzapine has been used very frequent to treat psychiatric patients and found to be very effective in both schizophrenic positive and negative symptoms. But the incidence report on olanzapine adverse drug reactions (ADR) is still limited. </sub></span></span></span></span></span></p><p><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><sub>Objective: </sub></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><sub>To study prescription pattern of olanzapine and its ADR in psychiatric patients. </sub></span></span></span></span></span></p><p><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><sub><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;">Method: </span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;">This was a retrospective study to review medical records of all psychiatric out-patients treated with olanzapine at Srinagarind hospital, Faculty of Medicine, Khon Kaen University during January 1</span></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: xx-small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: xx-small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: xx-small;">st </span></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;">2004 to December 31</span></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: xx-small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: xx-small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: xx-small;">st </span></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;">2010. </span></span></span></sub></span></span></p><p><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><sub>Results: </sub></span></span><sub><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;">There were 116 psychiatric out-patients receiving olanzapine. Their mean age was 48.24±18.31 years old. Sixty five patients (56.03%) had been prescribed olanzapine according to the indication(s) approved by the United States Food and Drug Administration (US FDA); of which </span></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;">40.52%, 27.59%, 17.24% were for patients with mood disorders, schizophrenia and dementia of the Alzheimer’s type and other dementia respectively. The usual and median daily dosage of olanzapine </span></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;">was 5-20 mg/day and 7.5 mg/day respectively. Adverse effects of olanzapine included weight gain </span></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;">was 48.28%, insomnia was 5.17%, extrapyramidal symptoms was 2.59%, increased sleeping hours was 1.72% and constipation was 0.86%. Regarding process indicators, effectiveness monitoring was done in 6.89% and safety monitoring of olanzapine prescription: at least once a year of complete blood count monitoring and lipid profile monitoring once every five years were done in 16.38% and 17.24% of the patients respectively. </span></span></span></sub></span></span></p><p><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><span style="color: #221e1f; font-size: small;"><sub>Conclusion: </sub></span></span><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><span style="color: #221e1f; font-family: UPC-Cordia,UPC-Cordia; font-size: small;"><sub>The olanzapine prescription, during 2004 - 2010, for psychiatric outpatients at Srinagarind Hospital, according to US FDA approval was found in 56.03%, the daily dosage was 5-20 mg/day. The most common side effect was weight gain. The effectiveness was done in 6.89% and safety monitoring was assessed in less than one-fifth of the patients.</sub></span></span></span></span></span></p>}, number={4}, journal={Journal of the Psychiatric Association of Thailand}, author={Chanthawong, Suthan and Paholpak, Pattharee and Junnamom, Samai and Subongkot, Suphat and Patthanasetthanon, Denpong and Boontawee, Wilaiwan and Shoora, Amornrat and Paholpak, Suchat}, year={2013}, month={Feb.}, pages={447–454} }